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Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns

Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns
研究产前接触双酚 A 对小鼠大脑的影响,特别是神经元迁移和表观遗传改变
批准号:
20310036
负责人:
FUSHIKI Shinji
金额:
$12.31万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We demonstrated that prenatal and lactational exposure to bisphenol A(BPA) affected fetal brain development, resulting in disturbed murine behavior accompanied with disrupted neurotransmitter system, including monoamines, in the postnatal development period and in adult mice. We also demonstrated that epigenetic alterations in promoter-associated CpG islands might underlie some of the effects on brain development after exposure to BPA.
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会议论文
DOI: 10.1016/j.braindev.2010.12.011
发表时间: 2012-01-01
期刊: BRAIN & DEVELOPMENT
影响因子: 1.7
作者: [Nakamura, Keiko, Itoh, Kyoko, Fushiki, Shinji]
通讯作者: Fushiki, Shinji
DOI: --
发表时间: 2009
期刊: 脳と発達 41
影响因子: --
作者: [久保田健夫, 伏木信次]
通讯作者: 伏木信次
環境化学物質の胎生期曝露と脳形成障害.シンポジウム「脳形成障害とオミックス」
产前接触环境化学物质和大脑形成障碍。研讨会“大脑形成障碍和组学”
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Atsushi Ishii, Oluf Langhelle, 伊東恭子]
通讯作者: 伊東恭子
Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. 2008 ; 376 : 563-7.
接触低剂量双酚 A 后胎儿小鼠前脑表观基因组变化的全基因组分析。2008;
DOI: --
发表时间: 2008
期刊: Biochem Biophys Res Commun. 376
影响因子: --
作者: [Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S.]
通讯作者: Fushiki S.
15
    Effects of endocrine disruptors on developing brain, with special reference to gene expression.
    • 批准号:
      15390334
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.54万
    • 财政年份:
      2003
    • 负责人:
      FUSHIKI Shinji
    • 依托单位:
    Functional analysis of neuronal migration-associated genes in murine brains by in utero gene transfer techniques with GFP reporter genes.
    • 批准号:
      13470213
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.41万
    • 财政年份:
      2001
    • 负责人:
      FUSHIKI Shinji
    • 依托单位:
    Search for genes involved in neuronal migration in cerebral cortex of X-irradiated embryonic mice
    • 批准号:
      11470222
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $9.15万
    • 财政年份:
      1999
    • 负责人:
      FUSHIKI Shinji
    • 依托单位:
    Pathogenesis of experimentally-induced heterotopia, with special reference to apoptosis and gap junctional communication.
    • 批准号:
      08457290
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $3.9万
    • 财政年份:
      1996
    • 负责人:
      FUSHIKI Shinji
    • 依托单位:
    海外基金