Cross-Coupling through Selective Cleavage of C-H and C-C Bonds

通过 C-H 和 C-C 键的选择性断裂进行交叉偶联

• 批准号: 20350050
• 负责人: MIURA Masahiro
• 金额: $ 12.73万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20350050/
• 关键词: 合成化学; クロスカップリング; 炭素結合; 遷移金属触媒; パイ共役分子

The coupling reaction of suitably functionalized aromatic and heteroaromatic substrates with aryl halides, alkenes, and alkynes proceeded effectively in the presence of a palladium or rhodium catalyst. Especially, aromatic carboxylic acids was found to undergo multi-coupling via C-H and C-C bond cleavages to afford structurally interesting pi-conjugated compounds. Furthermore, a number of C-H transformation reactions of aromatic compounds by using copper and nickel catalysts have been developed.

在钯或铑催化剂的存在下，适当功能化的芳香族和杂芳香族底物与芳基卤化物、烯烃和炔的偶联反应有效地进行。特别是芳香族羧酸，通过C-H和C-C键的裂解进行多重偶联，形成了结构上有趣的偶联化合物。此外，还开发了一些以铜和镍为催化剂的芳香族化合物C-H转化反应。

项目成果

Nickel-Catalyzed Direct C-H Arylation and Alkenylation of Heteroarenes with Organosilicon Reagents

• DOI: 10.1002/anie.200906996
• 发表时间: 2010-01-01
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Hachiya, Hitoshi;Hirano, Koji;Miura, Masahiro
• 通讯作者: Miura, Masahiro

炭素-水素結合切断を経る触媒的芳香族カップリング

通过碳氢键断裂催化芳族偶联

• 发表时间: 2010
• 作者: Y.Morita;K Sakamoto;他6名;三浦雅博
• 通讯作者: 三浦雅博

Oxidative Nickel-Air Catalysis in C-H Arylation: Direct Cross-Coupling of Azoles with Arylboronic Acids using Air as Sole Oxidant

• DOI: 10.1002/cctc.201000223
• 发表时间: 2010-11-01
• 期刊: CHEMCATCHEM
• 影响因子: 4.5
• 作者: Hachiya, Hitoshi;Hirano, Koji;Miura, Masahiro
• 通讯作者: Miura, Masahiro

A New Entry of Amination Reagents for Heteroaromatic C-H Bonds: Copper-Catalyzed Direct Amination of Azoles with Chloroamines at Room Temperature

• DOI: 10.1021/ja101939r
• 发表时间: 2010-05-26
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Kawano, Tsuyoshi;Hirano, Koji;Miura, Masahiro
• 通讯作者: Miura, Masahiro

Synthesis of stilbene and distyrylbenzene derivatives through rhodium-catalyzed ortho-olefination and decarboxylation of benzoic acids.

• DOI: 10.1021/ol1027392
• 发表时间: 2010-11
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Satoshi Mochida;K. Hirano;T. Satoh;M. Miura