Development of Oxidative Cyclization Reactions via C-H CleavageBased on First Row Transition Metal Catalysts

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We have focused on the potential of first row transition metals, in particular, copper salts, and succeeded in the development of unique catalytic activity of copper/O2systems. Namely, the copper-catalyzed oxidative direct cyclization between N-methylanilines and electron-deficient olefins proceeded through C-H cleavage even under ambient conditions. In addition, when a similar copper/oxygen catalyst was applied to the reaction of heteroarenes with sulfoximines, the direct C-N bond formation occurred via both C-H and C-N cleavages.