Functional analysis of focal adhesion proteins-sensors and re gulators for microenvironment

我们已经证明，vinexin，一种局灶黏附蛋白，抑制肿瘤细胞迁移，但通过控制生长因子受体的定位促进皮肤伤口愈合。我们还表明，与vinexin结合的肌动蛋白成核因子WAVE2将camp依赖性激酶招募到膜突起并促进膜突起。此外，另一种葡萄蛋白结合蛋白Dlg5可以调节纤维连接蛋白（一种细胞外基质）的分泌。综上所述，这些结果表明黏附蛋白作为细胞微环境的传感器和调节剂的功能。

We have shown that vinexin, a focal adhesion protein, inhibits tumor cell migration but promotes cutaneous wound healing by controlling the localization of growth factor receptors. We have also shown that WAVE2, an actin-nucleating factor that binds to vinexin, recruits cAMP-dependent kinase to the membrane protrusion and promotes the protrusion. Furthermore, another vinexin-binding protein Dlg5 can regulate the secretion of fibronectin, a extracellular matrix. Together, these results indicate the function of focal adhesion proteins as sensors and regulators for cellular microenvironment.