Lung cancer classification based on oncogene addiction
Lung cancer classification based on oncogene addiction
批准号:
20390105
负责人:
ISHIKAWA Yuichi
金额:
$5.49万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
我们与济济医学院H.Manu教授合作,报告了5例EML4-ALK易位的肺癌病例,随后确定了另外6例此类病例。有趣的是,这些肿瘤都是腺癌,缺乏EGFR、K-ras和c-Met癌基因突变。这一发现清楚地表明,ALK易位与EGFR、K-RAS和c-MET突变是相互排斥的,并强烈提示肺腺癌可以根据癌基因的变化进行分类。
英文摘要
We reported 5 lung cancer cases with EML4-ALK translocation in collaboration with Prof. H. Manu, Jichi Medical College, followed by identifying further 6 such cases. Interestingly, all these tumors were adenocarcinoma and lacked oncogene mutations of EGFR, K-ras and c-Met. This findings clearly indicated that ALK translocation was mutually exclusive from EGFR, K-RAS and c-MET mutations and strongly suggest that lung adenocarcinoma can be classified by oncogene changes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Cancer of unknown primary site : a review of 28 cases and the efficacy of cisplatin/docetaxel therapy at a single institute in Japan.
原发部位不明的癌症:日本一家机构对 28 例病例的回顾以及顺铂/多西他赛治疗的疗效。
DOI:
--
发表时间:
2010
期刊:
Acta Med Okayama. 64(5)
影响因子:
--
作者:
[Nishimori H, Takahashi S, Kiura K, Ennishi D, Kobayashi T, Sano K, Shinozaki E, Yokoyama M, Mishima Y, Terui Y, Chin K, Mizunuma N, Ito Y, Nishimura S, Takeuchi K, Ishikawa Y, Oguchi M, Tanimoto M, Hatake K]
通讯作者:
Hatake K
DOI:
10.1111/j.1442-2042.2010.02569.x
发表时间:
2010-08-01
期刊:
INTERNATIONAL JOURNAL OF UROLOGY
影响因子:
2.6
作者:
[Yamamoto, Shinya, Kawakami, Satoru, Fukui, Iwao]
通讯作者:
Fukui, Iwao
DOI:
10.1158/0008-5472.can-10-0801
发表时间:
2010-11-15
期刊:
CANCER RESEARCH
影响因子:
11.2
作者:
[Takeuchi, Shinji, Takahashi, Akiko, Ohtani, Naoko]
通讯作者:
Ohtani, Naoko
微小乳頭状腺癌・腸型腺癌
微乳头状腺癌/肠型腺癌
DOI:
--
发表时间:
2010
期刊:
病理と臨床 28(3)
影响因子:
--
作者:
[千田隆夫, 野村隆士, 向後晶子, 尾之内高慶, 山田源, 二宮浩範,石川雄一]
通讯作者:
二宮浩範,石川雄一
New aspects of pathological diagnosis and classification of cancer : focusing on miRNA expression and signaling pathways.
癌症病理诊断和分类的新方面:关注miRNA表达和信号通路。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Choi YL, Ishikawa Y, et al., 山田源, 石川雄一, Gen Yamada, 石川雄一]
通讯作者:
石川雄一
共 45 条
Regulation of cytoplasmic HDACs relating HSP90 protein
-
批准号:25860965
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.25万
-
财政年份:2013
-
负责人:ISHIKAWA Yuichi
-
依托单位:
A study based on geographical research of TOD in middle-sized cities in local areas
-
批准号:23520963
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.0万
-
财政年份:2011
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Creating a New Functional Fluid stemming from the Mixture of"Ionic Liquid - Magnetic particle - Nano Carbon"
-
批准号:23655181
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.58万
-
财政年份:2011
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Synthesis of novel inhibitors of hypoxia-inducible factor-1 transcriptional pathway based on natural products
-
批准号:22710223
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.08万
-
财政年份:2010
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Role of endothelial lipase in serum HDL cholesterol level and life style
-
批准号:20590825
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2008
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Tumor development mechanism and its risk evaluation in Werner syndrome
-
批准号:15590326
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2003
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Adsorption behavior of protein, porphyrins and lipid onto the oil/water interface -Estimation with the laser evanescent wave at the interface.
-
批准号:14340221
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.6万
-
财政年份:2002
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Role of chylomicron remnants in vascular remodeling
-
批准号:13670711
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2001
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Importance of Multi-phosphate Lipid for Regulating the Initiator of Gene replication.
-
批准号:11480167
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$10.05万
-
财政年份:1999
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Roles of transbronchial factors including cigarette smoke and asbestos for rapidly increasing lungcancer
-
批准号:11470052
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.16万
-
财政年份:1999
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Regulation by Leptin of Vascular Smooth Muscle Cells Proliferation and Migration
-
批准号:10670657
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:1998
-
负责人:ISHIKAWA Yuichi
-
依托单位:
Polyphiphilic Fluorocarbon Self-Assembly as an Asymmetric Field
-
批准号:09440243
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:ISHIKAWA Yuichi
-
依托单位:
The Trend of Multinucleation and the Characteristics of Suburban Nucleation in Japan
-
批准号:09680169
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.64万
-
财政年份:1997
-
负责人:ISHIKAWA Yuichi
-
依托单位:
CANCER INCIDENCE IN GENERAL POPULATION WITH HETEROZYGOUS MUTATIONS AT THE GENE LOCUS RESPONSIBLE FOR WERNER SYNDROME.
-
批准号:09670212
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:1997
-
负责人:ISHIKAWA Yuichi
-
依托单位:
海外基金