Lung cancer classification based on oncogene addiction

基于癌基因成瘾的肺癌分类

• 批准号: 20390105
• 负责人: ISHIKAWA Yuichi
• 金额: $ 5.49万
• 依托单位: Japanese Foundation For Cancer Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390105/
• 关键词: 肺癌; 遺伝子転座; キナーゼ; 組織型; EML4-ALK融合遺伝子; EGFR変異

We reported 5 lung cancer cases with EML4-ALK translocation in collaboration with Prof. H. Manu, Jichi Medical College, followed by identifying further 6 such cases. Interestingly, all these tumors were adenocarcinoma and lacked oncogene mutations of EGFR, K-ras and c-Met. This findings clearly indicated that ALK translocation was mutually exclusive from EGFR, K-RAS and c-MET mutations and strongly suggest that lung adenocarcinoma can be classified by oncogene changes.

我们与暨南医科大学H. Manu教授合作报道了5例肺癌EML4-ALK易位，随后又确定了6例此类病例。有趣的是，所有这些肿瘤都是腺癌，缺乏EGFR、K-ras和c-Met的癌基因突变。这一发现清楚地表明，ALK易位与EGFR、K-RAS和c-MET突变是相互排斥的，并强烈提示肺腺癌可以通过癌基因的变化进行分类。

项目成果

Cancer of unknown primary site : a review of 28 cases and the efficacy of cisplatin/docetaxel therapy at a single institute in Japan.

原发部位不明的癌症：日本一家机构对 28 例病例的回顾以及顺铂/多西他赛治疗的疗效。

• 发表时间: 2010
• 期刊: Acta Med Okayama. 64(5)
• 作者: Nishimori H;Takahashi S;Kiura K;Ennishi D;Kobayashi T;Sano K;Shinozaki E;Yokoyama M;Mishima Y;Terui Y;Chin K;Mizunuma N;Ito Y;Nishimura S;Takeuchi K;Ishikawa Y;Oguchi M;Tanimoto M;Hatake K
• 通讯作者: Hatake K

Feasibility of antegrade radical prostatectomy for clinically locally advanced prostate cancer: a comparative study with clinically localized disease

• DOI: 10.1111/j.1442-2042.2010.02569.x
• 发表时间: 2010-08-01
• 期刊: INTERNATIONAL JOURNAL OF UROLOGY
• 影响因子: 2.6
• 作者: Yamamoto, Shinya;Kawakami, Satoru;Fukui, Iwao
• 通讯作者: Fukui, Iwao

Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo

• DOI: 10.1158/0008-5472.can-10-0801
• 发表时间: 2010-11-15
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Takeuchi, Shinji;Takahashi, Akiko;Ohtani, Naoko
• 通讯作者: Ohtani, Naoko

微小乳頭状腺癌・腸型腺癌

微乳头状腺癌/肠型腺癌

• 发表时间: 2010
• 期刊: 病理と臨床 28(3)
• 作者: 千田隆夫;野村隆士;向後晶子;尾之内高慶;山田源;二宮浩範,石川雄一
• 通讯作者: 二宮浩範,石川雄一

New aspects of pathological diagnosis and classification of cancer : focusing on miRNA expression and signaling pathways.

癌症病理诊断和分类的新方面：关注miRNA表达和信号通路。

• 发表时间: 2010
• 作者: Choi YL;Ishikawa Y;et al.;山田源;石川雄一;Gen Yamada;石川雄一
• 通讯作者: 石川雄一