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Lung cancer classification based on oncogene addiction

Lung cancer classification based on oncogene addiction
基于癌基因成瘾的肺癌分类
批准号:
20390105
负责人:
ISHIKAWA Yuichi
金额:
$5.49万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

ISHIKAWA Yuichi的其他基金

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相关文献

中文摘要
翻译
我们与济济医学院H.Manu教授合作,报告了5例EML4-ALK易位的肺癌病例,随后确定了另外6例此类病例。有趣的是,这些肿瘤都是腺癌,缺乏EGFR、K-ras和c-Met癌基因突变。这一发现清楚地表明,ALK易位与EGFR、K-RAS和c-MET突变是相互排斥的,并强烈提示肺腺癌可以根据癌基因的变化进行分类。
英文摘要
We reported 5 lung cancer cases with EML4-ALK translocation in collaboration with Prof. H. Manu, Jichi Medical College, followed by identifying further 6 such cases. Interestingly, all these tumors were adenocarcinoma and lacked oncogene mutations of EGFR, K-ras and c-Met. This findings clearly indicated that ALK translocation was mutually exclusive from EGFR, K-RAS and c-MET mutations and strongly suggest that lung adenocarcinoma can be classified by oncogene changes.
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会议论文
Cancer of unknown primary site : a review of 28 cases and the efficacy of cisplatin/docetaxel therapy at a single institute in Japan.
原发部位不明的癌症:日本一家机构对 28 例病例的回顾以及顺铂/多西他赛治疗的疗效。
DOI: --
发表时间: 2010
期刊: Acta Med Okayama. 64(5)
影响因子: --
作者: [Nishimori H, Takahashi S, Kiura K, Ennishi D, Kobayashi T, Sano K, Shinozaki E, Yokoyama M, Mishima Y, Terui Y, Chin K, Mizunuma N, Ito Y, Nishimura S, Takeuchi K, Ishikawa Y, Oguchi M, Tanimoto M, Hatake K]
通讯作者: Hatake K
DOI: 10.1111/j.1442-2042.2010.02569.x
发表时间: 2010-08-01
期刊: INTERNATIONAL JOURNAL OF UROLOGY
影响因子: 2.6
作者: [Yamamoto, Shinya, Kawakami, Satoru, Fukui, Iwao]
通讯作者: Fukui, Iwao
DOI: 10.1158/0008-5472.can-10-0801
发表时间: 2010-11-15
期刊: CANCER RESEARCH
影响因子: 11.2
作者: [Takeuchi, Shinji, Takahashi, Akiko, Ohtani, Naoko]
通讯作者: Ohtani, Naoko
微小乳頭状腺癌・腸型腺癌
微乳头状腺癌/肠型腺癌
DOI: --
发表时间: 2010
期刊: 病理と臨床 28(3)
影响因子: --
作者: [千田隆夫, 野村隆士, 向後晶子, 尾之内高慶, 山田源, 二宮浩範,石川雄一]
通讯作者: 二宮浩範,石川雄一
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