Role of endothelial lipase in serum HDL cholesterol level and life style

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High-density lipoprotein cholesterol (HDL-C) is a negative risk factor for atherosclerosis. Endothelial lipase (EL) is a regulator of plasma HDL levels. This study was undertaken to clarify the role of EL in serum HDL-C level and life style. Serum EL protein levels were inversely correlated with serum HDL-C levels. Pitavastatin decreased EL levels and increased HDL levels. Serum EL activity was inversely correlated with serum HDL-C levels, and higher in patients with coronary artery disease compared to control subjects. In animal models of low HDL levels, inhibition of EL resulted in a raise in plasma HDL-C levels. Thus, EL is a determinant of plasma HDL levels in humans, and EL inhibition would be useful for HDL-raising therapy.