A study of HIV-1 escape mutants selected by cellular immunity

细胞免疫选择的HIV-1逃逸突变体的研究

• 批准号: 20390134
• 负责人: TAKIGUCHI Masafumi
• 金额: $ 12.48万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390134/
• 关键词: 感染防御; ワクチン; 免疫逃避; CTL

We identified novel 3 escape mutations from HIV-1-specific CTLs. We analyzed one escape mutation of them, RT 135 mutation, and found that this mutation accumulated in 9 cohorts. In addition, we showed the accumulation of other 13 escape mutations in these cohorts. These findings demonstrated strong evidence of HIV adaptation to HLA at a population level.

我们从HIV-1特异性CTL中鉴定了3种新的逃逸突变。我们分析了其中一个逃逸突变，RT 135突变，发现该突变在9个队列中积累。此外，我们还发现了其他13种逃逸突变在这些队列中的积累。这些发现证明了HIV在人群水平上适应HLA的强有力证据。

项目成果

(*equally contribution) Adaptation of HIV-1 to Human Leukocyte

(*同等贡献) HIV-1 对人类白细胞的适应

• 发表时间: 2009
• 期刊: Antigen class I. Nature 458
• 作者: Yuka Kawashima;Katja Pfafferott;John Frater;PhilipPa Matthews;Rebecca Payne;Marylyn Addo;Hiroyuki Gatanaga;Mamoru Fujiwara;Atsuko Hachiya;Hirokazu Koizumi;Nozomi Kuse;Shinichi Oka;Masafumi Takiguchi;Philip Goulder
• 通讯作者: Philip Goulder

Selection of escape mutant by HLA-C-restricted HIV-1-specific cytotoxic T lymphocytes having a strong ability of to suppress HIV-1 replication

HLA-C限制性HIV-1特异性细胞毒性T淋巴细胞筛选出具有强大抑制HIV-1复制能力的逃逸突变体

• 发表时间: 2009
• 作者: Kazutaka Honda;M.Hashimoto;K.Sakai;T.Akahoshi;Shinichi Oka;Masafumi Takiguchi
• 通讯作者: Masafumi Takiguchi

Differentin vivo effects of HIV-1immunodominant epitope-specific CTLson selection of escape mutant viruses

HIV-1免疫显性表位特异性CTL对逃逸突变病毒选择的不同体内效应

• 发表时间: 2010
• 期刊: Journal of Virology
• 影响因子: 5.4
• 作者: Koizumi H;Hashimoto M;Fujiwara M,Murakoshi H;Chikata T;Borghan MA,Hachiya A;Kawashima Y;Takata H;UenoT;Oka S;Takiguchi M
• 通讯作者: Takiguchi M

Adaptation of HIV-1 to human leukocyte antigen class I.

• DOI: 10.1038/nature07746
• 发表时间: 2009-04-02
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Kawashima, Yuka;Pfafferott, Katja;Frater, John;Matthews, Philippa;Payne, Rebecca;Addo, Marylyn;Gatanaga, Hiroyuki;Fujiwara, Mamoru;Hachiya, Atsuko;Koizumi, Hirokazu;Kuse, Nozomi;Oka, Shinichi;Duda, Anna;Prendergast, Andrew;Crawford, Hayley;Leslie, Alasdair;Brumme, Zabrina;Brumme, Chanson;Allen, Todd;Brander, Christian;Kaslow, Richard;Tang, James;Hunter, Eric;Allen, Susan;Mulenga, Joseph;Branch, Songee;Roach, Tim;John, Mina;Mallal, Simon;Ogwu, Anthony;Shapiro, Roger;Prado, Julia G.;Fidler, Sarah;Weber, Jonathan;Pybus, Oliver G.;Klenerman, Paul;Ndung'u, Thumbi;Phillips, Rodney;Heckerman, David;Harrigan, P. Richard;Walker, Bruce D.;Takiguchi, Masafumi;Goulder, Philip
• 通讯作者: Goulder, Philip

Different Ability of Escape Mutant-Specific Cytotoxic T Cells to Suppress Replication of Escape Mutant and Wild-type HIV-1 in New Hosts

逃逸突变体特异性细胞毒性 T 细胞抑制逃逸突变体和野生型 HIV-1 在新宿主中复制的不同能力

• 发表时间: 2008
• 期刊: Journal of Virology 82
• 作者: Nogi T;Yasui N;Mihara E;Matsunaga Y;Noda M;Yamashita N;Toyofuku T;Uchiyama S;Goshima Y;Kumanogoh A;Takagi J.;Mamoru Fujiwara
• 通讯作者: Mamoru Fujiwara