Analysis of unidentified autoantigens for IEN type IgA pemphigus and anti-p200 pemphigoid
Analysis of unidentified autoantigens for IEN type IgA pemphigus and anti-p200 pemphigoid
批准号:
20390308
负责人:
HASHIMOTO Takashi
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We identified the autoantigen for anti-p200 pemphigoid as laminin gamma-1 by proteomics technique, produced recombinant proteins of laminin gamma-1, and established novel ELISA. We established new immunoprecipitation technique for IgA antibodies using protein M sepharose and cultured KU8 cells which were shown to produce plenty of autoantigen for IEN type IgA pemphigus. We identified the autoantigen as IgA secretary component by two-dimensional gel electrophoresis, immunoblotting and mass spectrometric analysis.
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Herpetiform pemphigus without anti-desmoglein 1/3 autoantibodies.
没有抗桥粒芯糖蛋白 1/3 自身抗体的疱疹样天疱疮。
DOI:
--
发表时间:
2010
期刊:
J Dermatol
影响因子:
3.1
作者:
[Nakashima H, Hashimoto T, et al.]
通讯作者:
et al.
A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicines
一例具有 Brunsting-Perry 类天疱疮临床特征的获得性大疱性表皮松解症,对秋水仙碱显示出良好的反应
DOI:
--
发表时间:
2009
期刊:
J Am Acad Dermatol 61
影响因子:
--
作者:
[Tanaka N, Hashimoto T, et al.]
通讯作者:
et al.
DOI:
10.1007/s00403-009-0972-4
发表时间:
2009-10-01
期刊:
ARCHIVES OF DERMATOLOGICAL RESEARCH
影响因子:
3
作者:
[Abreu-Velez, Ana Maria, Howard, Michael S., Hashimoto, Takashi]
通讯作者:
Hashimoto, Takashi
A clinical study of patients with pemphigus vulgaris and pemphigus foliaceus : an 11-year retrospective study (1996-2006).
寻常型天疱疮和落叶型天疱疮患者的临床研究:一项 11 年回顾性研究(1996-2006)。
DOI:
--
发表时间:
2008
期刊:
Clin Exp Dermatol 47
影响因子:
--
作者:
[Ishii N, Maeyama Y, Yasumoto S, Hashimoto T, et. al.]
通讯作者:
et. al.
DOI:
10.1073/pnas.0809230106
发表时间:
2009-02-24
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Dainichi, Teruki, Kurono, Sadamu, Hashimoto, Takashi]
通讯作者:
Hashimoto, Takashi
共 36 条
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