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Genome diversity associated with in montalization and establishment of endometrial cancer stem cell isolation

Genome diversity associated with in montalization and establishment of endometrial cancer stem cell isolation
与子宫内膜癌干细胞分离的蒙塔化和建立相关的基因组多样性
批准号:
20390435
负责人:
WAKE Norio
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
There is genome diversity in Ras/ERα/MDM2/p53/p21 signalosome. Genome diversity in these signalosome influences each gene function due to allelic expression difference. AED of MDM2 p1 promoter activity is defected frequently and influences MDM2 gene function in several genes are upregulated in endometrial cancer stem cells. Among these genes, antibodies are prepared against gene products expressed in all surface, establishing the efficient method to identify the cancer stem cells.
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会议论文
Cytoplasmic and stromal expression of laminin 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type
层粘连蛋白2链的细胞质和基质表达与胃肠道型卵巢粘液性肿瘤的浸润性侵袭相关
DOI: --
发表时间: 2011
期刊: Oncol Rep
影响因子: 4.2
作者: [Okuma E, Ohishi Y, Oda Y, Aishima S, Kurihara S, Nishimural, Yasunaga M, Kobayashi H, Wake N, Tsuneyoshi M]
通讯作者: Tsuneyoshi M
DOI: --
发表时间: 2008
期刊: Pathology international 58(4)
影响因子: --
作者: [Yasunaga, M., Ohishi , Y., Nishimura, I.,Tamiya, S., Iwasa, A. , Takagi , E., Inoue,T., Yahata, H., Kobayashi, H., Wake, N. ,Tsuneyoshi, M.]
通讯作者: M.
A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events.
通过对重复的单倍体基因组进行基因分型确定的明确的单倍型图谱发现了拷贝数变异事件中的主要单倍型偏好。
DOI: --
发表时间: 2010
期刊: Am.J.Hum.Genet. 86(6)
影响因子: --
作者: [Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K.]
通讯作者: Hayashi K.
Coincident expression of beta-catenin and cychn D1 in endometrial stromal tumors and related high-grade sarcomas.
β-连环蛋白和 cychn D1 在子宫内膜间质瘤和相关的高级肉瘤中同时表达。
DOI: --
发表时间: 2010
期刊: Mod Pathol 23(2)
影响因子: --
作者: [Kurihara S, Oda, Y, Ohishi, Y, Kaneki E, Kobayashi H, Wake N, Tsuneyoshi M]
通讯作者: Tsuneyoshi M
35
    Molecular targeted therapy by inducing cancer cell senesence
    • 批准号:
      14104014
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $72.47万
    • 财政年份:
      2002
    • 负责人:
      WAKE Norio
    • 依托单位:
    Molecular mechanism of endometrial carcinoma development and their application for the new molecular target therapy
    • 批准号:
      12470344
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.5万
    • 财政年份:
      2000
    • 负责人:
      WAKE Norio
    • 依托单位:
    Molecular mechanism of cell senescence
    • 批准号:
      11557121
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.64万
    • 财政年份:
      1999
    • 负责人:
      WAKE Norio
    • 依托单位:
    Molecular mechanism of endometrial cancer and its application to gene diagnosis
    • 批准号:
      09470362
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.86万
    • 财政年份:
      1997
    • 负责人:
      WAKE Norio
    • 依托单位:
    海外基金