Genome diversity associated with in montalization and establishment of endometrial cancer stem cell isolation
Genome diversity associated with in montalization and establishment of endometrial cancer stem cell isolation
批准号:
20390435
负责人:
WAKE Norio
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
There is genome diversity in Ras/ERα/MDM2/p53/p21 signalosome. Genome diversity in these signalosome influences each gene function due to allelic expression difference. AED of MDM2 p1 promoter activity is defected frequently and influences MDM2 gene function in several genes are upregulated in endometrial cancer stem cells. Among these genes, antibodies are prepared against gene products expressed in all surface, establishing the efficient method to identify the cancer stem cells.
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Cytoplasmic and stromal expression of laminin 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type
层粘连蛋白2链的细胞质和基质表达与胃肠道型卵巢粘液性肿瘤的浸润性侵袭相关
DOI:
--
发表时间:
2011
期刊:
Oncol Rep
影响因子:
4.2
作者:
[Okuma E, Ohishi Y, Oda Y, Aishima S, Kurihara S, Nishimural, Yasunaga M, Kobayashi H, Wake N, Tsuneyoshi M]
通讯作者:
Tsuneyoshi M
DOI:
--
发表时间:
2008
期刊:
Pathology international 58(4)
影响因子:
--
作者:
[Yasunaga, M., Ohishi , Y., Nishimura, I.,Tamiya, S., Iwasa, A. , Takagi , E., Inoue,T., Yahata, H., Kobayashi, H., Wake, N. ,Tsuneyoshi, M.]
通讯作者:
M.
A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events.
通过对重复的单倍体基因组进行基因分型确定的明确的单倍型图谱发现了拷贝数变异事件中的主要单倍型偏好。
DOI:
--
发表时间:
2010
期刊:
Am.J.Hum.Genet. 86(6)
影响因子:
--
作者:
[Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K.]
通讯作者:
Hayashi K.
Coincident expression of beta-catenin and cychn D1 in endometrial stromal tumors and related high-grade sarcomas.
β-连环蛋白和 cychn D1 在子宫内膜间质瘤和相关的高级肉瘤中同时表达。
DOI:
--
发表时间:
2010
期刊:
Mod Pathol 23(2)
影响因子:
--
作者:
[Kurihara S, Oda, Y, Ohishi, Y, Kaneki E, Kobayashi H, Wake N, Tsuneyoshi M]
通讯作者:
Tsuneyoshi M
CDIO Immunostaining distinguishes atypical polypoid adenomyofibroma(atypical polypoid adenomyoma)from endometrial carcinoma invading the myometrium.
CDIO免疫染色可区分非典型息肉样腺肌纤维瘤(非典型息肉样腺肌瘤)和侵入子宫肌层的子宫内膜癌。
DOI:
--
发表时间:
2008
期刊:
Human Pathology 39
影响因子:
--
作者:
[Ohishi Y, Kaku T, Kobayashi H, Aishima S, Umekita Y, Wake N, Tsuneyoshi M]
通讯作者:
Tsuneyoshi M
共 35 条
Molecular targeted therapy by inducing cancer cell senesence
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批准号:14104014
-
项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$72.47万
-
财政年份:2002
-
负责人:WAKE Norio
-
依托单位:
Molecular mechanism of endometrial carcinoma development and their application for the new molecular target therapy
-
批准号:12470344
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.5万
-
财政年份:2000
-
负责人:WAKE Norio
-
依托单位:
Molecular mechanism of cell senescence
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批准号:11557121
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.64万
-
财政年份:1999
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负责人:WAKE Norio
-
依托单位:
Molecular mechanism of endometrial cancer and its application to gene diagnosis
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批准号:09470362
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.86万
-
财政年份:1997
-
负责人:WAKE Norio
-
依托单位:
Development of new therapy for uterine cervical carcinoma
-
批准号:08557092
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$5.76万
-
财政年份:1996
-
负责人:WAKE Norio
-
依托单位:
Establishment of gene diagnosis and therapy for Endometrial carcinoma.
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批准号:07457391
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.67万
-
财政年份:1995
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负责人:WAKE Norio
-
依托单位:
Genetic Events Associated With Choriocarcinogenesis.
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批准号:07042006
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项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$4.99万
-
财政年份:1995
-
负责人:WAKE Norio
-
依托单位:
Development of gene diagnosis and therapy for endometrial cancers.
-
批准号:05454453
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.16万
-
财政年份:1993
-
负责人:WAKE Norio
-
依托单位:
Application of antisense oligo DNA to uterine cancers.
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批准号:05557073
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$5.57万
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财政年份:1993
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负责人:WAKE Norio
-
依托单位:
Genetic events associated with human endometrial carcinogenesis.
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批准号:03454399
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
-
财政年份:1991
-
负责人:WAKE Norio
-
依托单位:
Identification of a Chromosome Carrying a Putative Tumor Suppressor gene in Human Choriocarcinoma by Microcell-Mediated Chromosome Transfer.
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批准号:63480363
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.2万
-
财政年份:1988
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负责人:WAKE Norio
-
依托单位:
Transformation mechanism of human choriocarcinoma
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批准号:60570763
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1985
-
负责人:WAKE Norio
-
依托单位:
海外基金