Evaluation of potential to promote the differentiation of osteoblastic cells by immobilized cationic antimicrobial peptide, JH8194 which promotes the proliferation of mesenchymal stem cells

本研究旨在探讨组蛋白衍生的阳离子抗菌肽JH8194固定钛对成骨细胞（MC3T3-E1）分化的影响。根据前面描述的方法，用JH8194固定钛样品（Ti）。与对照和阻断ti相比，JH8194-Ti增强了MC3T3-E1中Runx2和OPN mRNA的表达以及ALPase的活性。综上所述，JH8194-Ti可能是缩短骨整合时间的潜在辅助物

The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration