Development of a light cured resin-BMP composite material intending to induce new bone formation in vivo

开发光固化树脂-BMP复合材料，旨在诱导体内新骨形成

• 批准号: 20390502
• 负责人: KAWAI Tatsushi
• 金额: $ 12.31万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390502/
• 关键词: 生体材料; 生物・生体工学; 再生医療; 光造形; biomaterial; tissue engineering; biological engineering; 3D modeling; バイオテクノロジー

In order to develop an implant material that has a potential to induce new bone formation adequate to the 3-dimentional shape that refrects to each clinical situation, a resin with BMP composite was assembled. According to the 3-Dimentional data obtaining from micro X-ray CT system, resin scaffold was made by means of 3D-SLS system, then combined with BMP. The composite material was implanted in vivo and new bone formation occurred surrounding tissue of the scaffold.

为了开发一种具有诱导新骨形成的潜力的植入材料，该新骨形成适合于反映每种临床情况的三维形状，组装了具有BMP复合物的树脂。根据显微X线CT扫描获得的三维数据，利用三维激光烧结系统制备树脂支架，并与BMP复合。将复合材料植入体内，支架周围组织发生新骨形成。

项目成果

Osteoinductive activity of BMP-Metal composite material

BMP-金属复合材料的骨诱导活性

• 发表时间: 2011
• 作者: Ueda;N.;Kawai;T.;Hayashi;T.;Tsuruta;S.;Taniyama;M.;Hamajima;S.;Sato;Y.;Kobayashi;S.;Ohno;Y.;Uematsu;Y
• 通讯作者: Y

The newly developed root canal filling materials.

新开发的根管充填材料。

• 发表时间: 2008
• 作者: Wanibe;H.;et. al.
• 通讯作者: et. al.

焼結二酸化チタン・デキストリン複合骨補填材の骨伝導性について

烧结二氧化钛/糊精复合骨移植材料的骨传导性研究

• 发表时间: 2010
• 作者: 浅井崇文;他
• 通讯作者: 他

Ca2+ promotes the calcification of induced bone-like tissue in vitro

Ca2促进体外诱导骨样组织钙化

• 发表时间: 2008
• 作者: T. Hayashi;T. Kawai;T. Asai;M. Okano;Y. Sato;M. Asakura
• 通讯作者: M. Asakura

The Basic experiment about the effective of sintered titanium dioxide as a bone filling material

烧结二氧化钛作为骨填充材料有效性的基础实验

• 发表时间: 2011
• 作者: Asai;T.;Hayashi;T.;Kuroki;K.;Mieki;A.;Kataoka;H.;Kawai;T
• 通讯作者: T