Development of Biomaterials which Induce Tissue and Organ

组织器官诱导生物材料的开发

基本信息

  • 批准号:
    12307047
  • 负责人:
  • 金额:
    $ 7.4万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 财政年份:
    2000
  • 资助国家:
    日本
  • 起止时间:
    2000 至 2001
  • 项目状态:
    已结题

项目摘要

It is elucidated that both HAP-BMP composite material, which was used as a frame works, and artificial membrane - BMP composite material induced new bone and cartilage , those are useful as tissue organ inducible biomaterials. However, outer shape of implant, which was constructed with BMP as a framework, should have smooth surface and no sharp edge. Therefore, lubricating the surface of HAP and delete of the sharp edge is remarkably important. It is very hard to induce new bone inside of the inner vacant space of tubules shape of HAP. It demonstrates that not only the BMP is a factor of bone induction but also another unknown factor influence the osteogenesity. VEGF(vascular endothelial growth factor) or some other factors could be a cofactor for the new bone formation.It is considered that this information contributes largely to the next project. All artificial membrane -BMP composite showed new bone formation, and those are applicable for the clinical usage, such as GTR method. When biodegradable membrane is used, induction of new cartilage in vitro was very hard. More basic research work is necessary on this material for the application to clinical usage. There was only one research report for the cartilage induction on the artificial membrane previously. New cartilage formation on acetate membrane was successfully performed in this project. This induction remained only cartilage stage and not progress to osteoinduction but new bone formation could be possible by transplanting this system in vivo. Consequently, two kinds of tissue organ biomaterials, which are HAP-BMP composite and artificial membrane - BMP composite, are developed through these experiments, and important information for the application of this material for the clinical usage was accumulated.
结果表明,以HAP-BMP复合材料为骨架材料和人工膜-BMP复合材料均可诱导新生骨和软骨,可作为组织器官诱导材料。然而,以BMP为骨架构建的种植体外外形应表面光滑,无尖锐边缘。因此,对HAP表面进行润滑和去除锋利的边缘是非常重要的。在HAP小管状的内部空腔内很难诱导新生骨。这表明BMP不仅是骨诱导因子,而且是影响成骨的另一个未知因子。VEGF(血管内皮生长因子)或其他一些因子可能是新骨形成的辅助因子。人们认为这些信息对下一个项目有很大的帮助。所有人工膜-BMP复合材料均能形成新骨,适用于临床应用,如GTR法。当使用生物可降解膜时,体外诱导新软骨非常困难。该材料的临床应用还需要更多的基础研究工作。在人工膜上诱导软骨的研究,以往仅有一篇报道。本项目成功地在醋酸膜上形成了新的软骨。这种诱导仅停留在软骨阶段,而没有进展到骨诱导,但通过在体内移植该系统可以形成新的骨。因此,通过这些实验,开发了两种组织器官生物材料,即HAP-BMP复合材料和人工膜-BMP复合材料,为该材料的临床应用积累了重要的信息。

项目成果

期刊论文数量(22)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
長谷川二郎: "最新歯科材料および技術.機器"シーエムシー. 348 (2000)
长谷川次郎:“最新牙科材料和技术。设备”CMC 348(2000)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Izawa, H., Hachiya, Y., Kawai, T., Muramatsu, K., Narita, Y., Ban, S., Yoshizawa, H.: "The Effect of Heat-Treated Human Bone Morphogenetic Protein on Clinical Implantation"Clin Orthop. 390. 252-258 (2001)
Izawa, H.、Hachiya, Y.、Kawai, T.、Muramatsu, K.、Narita, Y.、Ban, S.、Yoshizawa, H.:“热处理人骨形态发生蛋白对临床植入的影响”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Izawa, H., Hachiya, Y., Kawai, T., Muramatsu, K., Narita, Y., Ban, S., Yoshizawa, H.: "The Effect of Heat-Treated Human Bone morphogenetic Protein on Clinical Imprantation"Clin Orthop. 390. 252-258 (2001)
Izawa, H.、Hachiya, Y.、Kawai, T.、Muramatsu, K.、Narita, Y.、Ban, S.、Yoshizawa, H.:“热处理人骨形态发生蛋白对临床植入的影响”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Murakami, H., Mizuguchi, M., Hattori, M., Ito, Y., Kawai, T., Hasegawa, J.: "Effect of denture cleaner using ozone against methicillin-resistant staphylococcus aureus and E. coli T1 phage"Dental Materials Journal. 21(1). 53-60 (2002)
Murakami, H.、Mizuguchi, M.、Hattori, M.、Ito, Y.、Kawai, T.、Hasekawa, J.:“使用臭氧的假牙清洁剂对耐甲氧西林金黄色葡萄球菌和大肠杆菌 T1 噬菌体的效果”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Ban,S.: "Effect of Substrate Metals on Hydrothermal-Elecrtochermical Deosition of Apatite."Aichi-Gakuin Dental Science.. 13. 19-30 (2000)
Ban,S.:“基质金属对磷灰石水热电化学沉积的影响。”爱知学院牙科科学.. 13. 19-30 (2000)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

KAWAI Tatsushi其他文献

KAWAI Tatsushi的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('KAWAI Tatsushi', 18)}}的其他基金

development of implantable oseoinductive materials using polysaccharide and bone morphogenetic protein (BMP) combined 3D fabricated scaffold
使用多糖和骨形态发生蛋白 (BMP) 组合 3D 制造支架开发植入式声诱导材料
  • 批准号:
    23390454
  • 财政年份:
    2011
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of a light cured resin-BMP composite material intending to induce new bone formation in vivo
开发光固化树脂-BMP复合材料,旨在诱导体内新骨形成
  • 批准号:
    20390502
  • 财政年份:
    2008
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of Thin Resin Film-BMP Composite
树脂薄膜-BMP复合材料的研制
  • 批准号:
    18390527
  • 财政年份:
    2006
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of the noble biomaterial for re-implantation to host consisiting of chondrocyte culture system and titanium system
软骨细胞培养系统和钛系统组成的用于再植入宿主的高贵生物材料的开发
  • 批准号:
    16390571
  • 财政年份:
    2004
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Osteoinduction derived from cartilage, which induced on a composite polymer membrane with BMP
源自软骨的骨诱导,在带有 BMP 的复合聚合物膜上进行诱导
  • 批准号:
    14571873
  • 财政年份:
    2002
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of BMP-Metal composite
BMP-金属复合材料的开发
  • 批准号:
    09672023
  • 财政年份:
    1997
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of biocompatible metal-BMP composit
生物相容性金属-BMP复合材料的开发
  • 批准号:
    02670882
  • 财政年份:
    1990
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

相似海外基金

Collaborative Research: Mechanoregulation of Amnion Patterning through Activation of Bone Morphogenetic Protein Signaling
合作研究:通过激活骨形态发生蛋白信号传导对羊膜模式进行机械调节
  • 批准号:
    2325361
  • 财政年份:
    2023
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Standard Grant
Interpreting Bone Morphogenetic Protein Gradients in Vertebrate Development
解释脊椎动物发育中的骨形态发生蛋白梯度
  • 批准号:
    10677094
  • 财政年份:
    2023
  • 资助金额:
    $ 7.4万
  • 项目类别:
Collaborative Research: Mechanoregulation of Amnion Patterning through Activation of Bone Morphogenetic Protein Signaling
合作研究:通过激活骨形态发生蛋白信号传导对羊膜模式进行机械调节
  • 批准号:
    2325360
  • 财政年份:
    2023
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Standard Grant
Role of SIN3a in the epigenetic regulation of the Bone Morphogenetic Protein Receptor Type 2 in pulmonary arterial hypertension
SIN3a 在肺动脉高压 2 型骨形态发生蛋白受体表观遗传调控中的作用
  • 批准号:
    10508964
  • 财政年份:
    2022
  • 资助金额:
    $ 7.4万
  • 项目类别:
Investigating the kinetics of endothelial Bone Morphogenetic Protein 9 (BMP9) signalling in Pulmonary Arterial Hypertension
研究肺动脉高压中内皮骨形态发生蛋白 9 (BMP9) 信号传导的动力学
  • 批准号:
    486268
  • 财政年份:
    2022
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Studentship Programs
Characterization of a Droplet Microfluidic High Throughput Screening Device and Developing Machine Learning Algorithms to Study the Bone Morphogenetic Protein Signaling Pathway
液滴微流体高通量筛选装置的表征和开发机器学习算法来研究骨形态发生蛋白信号通路
  • 批准号:
    10553603
  • 财政年份:
    2022
  • 资助金额:
    $ 7.4万
  • 项目类别:
Characterization of a Droplet Microfluidic High Throughput Screening Device and Developing Machine Learning Algorithms to Study the Bone Morphogenetic Protein Signaling Pathway
液滴微流体高通量筛选装置的表征和开发机器学习算法来研究骨形态发生蛋白信号通路
  • 批准号:
    10390063
  • 财政年份:
    2022
  • 资助金额:
    $ 7.4万
  • 项目类别:
Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide Dynamics and the Pathobiology of Pulmonary Arterial Hypertension
探讨内皮骨形态发生蛋白受体 2 缺失对磷酸肌醇动力学和肺动脉高压病理学的影响
  • 批准号:
    466835
  • 财政年份:
    2021
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Studentship Programs
Bone Morphogenetic Protein 7 in Hyaline Cartilage Lineage Commitment
透明软骨谱系承诺中的骨形态发生蛋白 7
  • 批准号:
    548048-2020
  • 财政年份:
    2021
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Targeting bone morphogenetic protein-9 as an angioproliferative switch in pulmonary arterial hypertension
靶向骨形态发生蛋白 9 作为肺动脉高压的血管增殖开关
  • 批准号:
    443722
  • 财政年份:
    2021
  • 资助金额:
    $ 7.4万
  • 项目类别:
    Operating Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了