Involvement of Hox genes in subgroup specific motoneuron death

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Major results of the present study are as follows:(1) The rostral ends of HoxC5 and HoxC6 expressions well correspond to the rostral and caudal borders of the segments with early cervical motoneuron death, respectively.(2) FoxP1 transcription factor that is known to cooperate with Hox genes for inducing specific motoneuron subgroups is found in dying motoneurons. However, functional significance of FoxP1 in early cervical motoneuron death has not been elucidated yet.(3) In the avian cervical cord, there are branchial motoneurons that express Phox2b and never die during the period of early cervical motoneuron death.