To evaluate the effect of low reactive level laser on overactive bladder

我们重新考虑了低反应水平激光对正常大鼠膀胱功能和脊髓损伤、帕金森病、膀胱炎等多种情况下膀胱过度活动大鼠膀胱功能的影响，并评价了这种新方法的安全性。基于这些结果，我们在日本申请了专利，并决定向医院的机构审查委员会/伦理委员会申请研究者发起的试验。我们还开发了一种新的方法和设计，使用近红外光谱（NIRS）来评估尿急作为膀胱过度活动的主要症状和逼尿肌过度活动作为膀胱过度活动的病理背景。并对该方法和装置在人体中的实用性进行了评估和考虑。我们也为这个新想法在日本申请了专利。

We reconsidered the effect of low reactive level laser on bladder function in normal rats and overactive bladder in rats with various conditions such as spinal cord injury, Parkinson's disease and cystitis, and evaluated the safety of this new method. Based on these results, we apply for a patent in Japan and we decided to apply for a investigator-initiated trial to institutional review board/ethics committees in our hospital. We also developed a new method and devise by using near-infrared spectroscopy (NIRS) to evaluate urinary urgency as a main symptom of overactive bladder and detrusor overactivity as a pathologic background of overactive bladder. And we evaluated and considered the usefulness of this method and device in human. We also apply for a patent in Japan about this new idea.