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Effects of exercise-induced interleukin-6 secretion on protein synthesis in skeletal muscle

Effects of exercise-induced interleukin-6 secretion on protein synthesis in skeletal muscle
运动诱导的白细胞介素 6 分泌对骨骼肌蛋白质合成的影响
批准号:
20500577
负责人:
NAKAI Naoya
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Murine myoblast cell line was mechanically stretched as a model for exercise-induced muscle contraction. Mechanical stretch increased the gene expression of interleukin-6 and activated the protein translation initiation. Stretch-induced activation of the protein translation initiation was completely blocked by tyrosin kinase inhibitor, genistein. Among the cellular protein which is activated by tyrosine kinase, phospholipase C was important for the signal transduction of mechanical stretch-induced activation of protein translation initiation.
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会议论文
Myonucleus-related properties in soleus muscle fibers of mdx mice.
mdx 小鼠比目鱼肌纤维的肌核相关特性。
DOI: --
发表时间: 2010
期刊: Cell.Tissue.Organ.
影响因子: --
作者: [Terada M., et al.]
通讯作者: et al.
Tyrosine phosphorylation regulates mechanical stretch-induced activation of protein translation initiation in C2C12 myoblast
酪氨酸磷酸化调节 C2C12 成肌细胞中机械拉伸诱导的蛋白质翻译起始激活
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Nakai, N., Kawano, F., Oke, Y., Nomura, S., Ohira, T., Fujita, R., Ohira, Y.]
通讯作者: Y.
Mechanical stretch induces activation of eukaryotic elongation factor 2 in C2C12 myoblasts
机械拉伸诱导 C2C12 成肌细胞中真核伸长因子 2 的激活
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [N. Nakai, F. Kawano, Y. Oke, S. Nomura, M. Terada, T. Ohira, and Y, Ohira]
通讯作者: Ohira
DOI: 10.1152/ajpcell.00497.2007
发表时间: 2008-08-01
期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
影响因子: 5.5
作者: [Kawano, Fuminori, Takeno, Yoshiaki, Ohira, Yoshinobu]
通讯作者: Ohira, Yoshinobu
15
    Skeletal muscle cell activation by atmospheric plasma exposure and application to tissues
    • 批准号:
      23650405
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      NAKAI Naoya
    • 依托单位:
    Investigation of the role of branched chain amino add on stimulation of protein synthesis and application for preservation and improvement of muscle mass
    • 批准号:
      18500509
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.57万
    • 财政年份:
      2006
    • 负责人:
      NAKAI Naoya
    • 依托单位:
    海外基金