Role of fibroblast growth factors on regenerating skeletal muscle

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To examine the relations between specific fibroblast growth factors (FGFs) and satellite cell activation during muscle regeneration in vivo, we measured mRNA expression of FGFs and myogenic markers in rat plantaris muscle after bupivacaine administration. FGF-1, FGF-5 and FGF-7 mRNAs after the treatment started to increase at the same time as MyoD and PCNA mRNAs. FGF-7 protein was expressed in immature muscle fiber nuclei and the extracellular matrix. These results indicate that FGF-7 is associated with specific myogenic marker expression during muscle regeneration. However, suppression of FGF-7 mRNA expression following short hairpin RNA administration did not change the expression of myogenic markers. Consequently, the role of FGF-7 during muscle regeneration in vivo remains unclear.