Molecular basis for the formation of translational repression complex that regulates stem cell differentiation
Molecular basis for the formation of translational repression complex that regulates stem cell differentiation
批准号:
20570111
负责人:
NAGATA Takashi
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Musashi1 (Msi1) is a neural protein that suppresses translation of target mRNAs and contributes in maintenance of cell stemness and tumorigenesis. We have determined the RNA recognition mechanism by Msi1. Minimal RNA sequence for Msi1, and the binding mechanism of Msi1 that we have elucidated would provide important clues to discover new target genes for Msi1. Meanwhile, we have determined the structure of PABP and identified its Msi1 binding sites. Finally, we have prepared a protocol for building protein and nucleic acid complex models that would support the structural analysis of translational repression complex.
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植物遺伝子の光制御に関連したGT-1タンパク質の構造と相互作用の研究""Structural and DNA binding analyses of GT-1 involved in the photoregulation of plant genes
参与植物基因光调节的 GT-1 的结构和 DNA 结合分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sohda M, Misumi Y, Yamamoto A, Nakamura N, Ogata S, Sakisaka S, Hirose S, Ikehara Y, Oda K, 藤本なつき]
通讯作者:
藤本なつき
Structural and functional analysis of the translational repression complex that plays a key role in differentiation regulation
在分化调节中起关键作用的翻译抑制复合体的结构和功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ohyama, T., Nagata, T., Katahira, M., 他]
通讯作者:
他
HIV遺伝子上でのAPOBEC3Gによるシチジンデアミネーション反応の動作機序
APOBEC3G对HIV基因胞苷脱氨反应的机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Furukawa, A., Nagata, T., Morishita, R, Sugiyama R., Takaku H., Takaori A., Ryo A., Katahira, M]
通讯作者:
M
Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure and interaction of the RNA aptamer against prion protein
实时监测具有抗HIV活性的APOBEC3G的酶促反应以及针对朊病毒蛋白的RNA适体的结构和相互作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Furukawa, A.]
通讯作者:
A.
Structures and interactions of 4'-thioDNA and RNA/DNA-binding proteins
4-thioDNA 和 RNA/DNA 结合蛋白的结构和相互作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yasuhiro Imafuku, Neil Thomas, 片平正人]
通讯作者:
片平正人
共 47 条
Towards the molecular basis of the ligand-binding mechanism and drug-discovery of TAM receptor tyrosine kinases
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批准号:23570146
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.58万
-
财政年份:2011
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负责人:NAGATA Takashi
-
依托单位:
Exploring Superoxide Chemistry in Clusters
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批准号:22550006
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2010
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负责人:NAGATA Takashi
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依托单位:
Structural Properties of Gas-Phase Solvated Electrons and Anions-Toward the Microscopic Understanding of Stabilization Mechanism-
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批准号:18550007
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:NAGATA Takashi
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依托单位:
Development of Novel Reactions in Cluster-Mediated Anion Chemistry
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批准号:15350006
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.98万
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财政年份:2003
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负责人:NAGATA Takashi
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依托单位:
Structures and Reactivities of Negatively-Charged Clusters in Supercritical Carbon Dioxide
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批准号:12440160
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.14万
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财政年份:2000
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负责人:NAGATA Takashi
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依托单位:
Reaction Control by Cluster-Mediaipd Chemistry
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批准号:11166217
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
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资助金额:$18.24万
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财政年份:1999
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负责人:NAGATA Takashi
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依托单位:
A Highly Productive Basin-Type-Multiple-Effect Coupled Solar Still
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批准号:10650220
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1998
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负责人:NAGATA Takashi
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依托单位:
Dynamics of Gas-Phase Clusters as Studied by Tune-Resolved Photoelectron
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批准号:09440210
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.49万
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财政年份:1997
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负责人:NAGATA Takashi
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依托单位:
Structures and Dynamics of Negatively-Charged Molecular Clusters
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批准号:06453015
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.03万
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财政年份:1994
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负责人:NAGATA Takashi
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依托单位:
Enhancement of Mass Transfer into a Falling Liquid Film by Two-Dimensional Waves
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批准号:05650201
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.47万
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财政年份:1993
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负责人:NAGATA Takashi
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依托单位:
Condensation Heat Transfer from Humid Air to a Horizontal tube
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批准号:60550158
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.96万
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财政年份:1985
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负责人:NAGATA Takashi
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依托单位:
海外基金