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Molecular basis for the formation of translational repression complex that regulates stem cell differentiation

Molecular basis for the formation of translational repression complex that regulates stem cell differentiation
调节干细胞分化的翻译抑制复合物形成的分子基础
批准号:
20570111
负责人:
NAGATA Takashi
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Musashi1 (Msi1) is a neural protein that suppresses translation of target mRNAs and contributes in maintenance of cell stemness and tumorigenesis. We have determined the RNA recognition mechanism by Msi1. Minimal RNA sequence for Msi1, and the binding mechanism of Msi1 that we have elucidated would provide important clues to discover new target genes for Msi1. Meanwhile, we have determined the structure of PABP and identified its Msi1 binding sites. Finally, we have prepared a protocol for building protein and nucleic acid complex models that would support the structural analysis of translational repression complex.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Sohda M, Misumi Y, Yamamoto A, Nakamura N, Ogata S, Sakisaka S, Hirose S, Ikehara Y, Oda K, 藤本なつき]
通讯作者: 藤本なつき
Structural and functional analysis of the translational repression complex that plays a key role in differentiation regulation
在分化调节中起关键作用的翻译抑制复合体的结构和功能分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ohyama, T., Nagata, T., Katahira, M., 他]
通讯作者:
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Furukawa, A., Nagata, T., Morishita, R, Sugiyama R., Takaku H., Takaori A., Ryo A., Katahira, M]
通讯作者: M
Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure and interaction of the RNA aptamer against prion protein
实时监测具有抗HIV活性的APOBEC3G的酶促反应以及针对朊病毒蛋白的RNA适体的结构和相互作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Furukawa, A.]
通讯作者: A.
47
    Towards the molecular basis of the ligand-binding mechanism and drug-discovery of TAM receptor tyrosine kinases
    • 批准号:
      23570146
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.58万
    • 财政年份:
      2011
    • 负责人:
      NAGATA Takashi
    • 依托单位:
    Exploring Superoxide Chemistry in Clusters
    • 批准号:
      22550006
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2010
    • 负责人:
      NAGATA Takashi
    • 依托单位:
    Structural Properties of Gas-Phase Solvated Electrons and Anions-Toward the Microscopic Understanding of Stabilization Mechanism-
    • 批准号:
      18550007
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.57万
    • 财政年份:
      2006
    • 负责人:
      NAGATA Takashi
    • 依托单位:
    Development of Novel Reactions in Cluster-Mediated Anion Chemistry
    • 批准号:
      15350006
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.98万
    • 财政年份:
      2003
    • 负责人:
      NAGATA Takashi
    • 依托单位:
    海外基金