Study on the mechanisms by which functional foods regulate androgen receptor function

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Androgen receptor regulates the expression of some genes involved in proliferation and progression of prostate cancer. In the present study, we identified hypoxia-inducible factor-1a (HIF-1a) and b-catenin as cooperative AR coactivators under hypoxic conditions and demonstrated the molecular mechanisms by which these coactivators enhanced AR transactivation. Furthermore, we constructed a rapid yeast bioassay for androgenic and anti-androgenic compounds based on the molecular mechanisms and analyzed anti-androgenic activity of food components.