Analysis of the functional interactions of factors concerned with histones in malignant transformation.

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Mutations in oncogene and tumor suppressor gene lead to malignant transformation. Dysregulation of DNA methylation and histone modification is also found in cancer. Epigenetic studies are also required to understand molecular mechanisms of carcinogenesis and tumorigenesis. Here, we revealed that epigenetics regulatory factors, which induced hepatocarcinogenesis, including histone acetyltransferase, histone methyltransferase, and histone variant, regulated gene expression of tumor marker, cell proliferation, and anchorage-independent growth.