Making and clinical application of supporting software for the optimal administration method of drug based on the PK/PD theory on the target-organ
Making and clinical application of supporting software for the optimal administration method of drug based on the PK/PD theory on the target-organ
基于靶器官PK/PD理论的药物最佳给药方式支撑软件的制作及临床应用
批准号：
20590146
负责人：
MORIKAWA Norifumi
金额：
$3.16万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
中文摘要
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英文摘要
We made a new system which collected blood and biological samples in patient at our research collaboration hospitals. It established the drug concentration measurement methods of those delivered samples of patients. Those measured drug concentration results were sent to the research collaboration hospitals by e-mail. It collected the pharmacokinetic (PK) and the pharmacodynamics (PD) data of drug in each patient. It estimated the population pharmacokinetic parameter (PPK) from the gathered individual PK data. We made the supporting software for the optimal administration method of drug based on the PK/PD theory on the target-organ used by the estimated PPK.
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Penetration and exposure of cefotiam into the peritoneal fluid of abdominal surgery patients after intravenous administration
腹部手术患者静脉给药后头孢替安在腹腔液中的渗透和暴露
腹部手术患者静脉给药后头孢替安在腹腔液中的渗透和暴露
DOI：
--
发表时间：
2008
期刊：
J.Chemother. 20
影响因子：
--
作者：
[Ikawa K, Morikawa N, Fukuhara K, Hayato S, Ikeda K, Soga Y, Ohge H, Sueda T]
通讯作者：
Sueda T
Dexamethasone reduced voriconazole plasma level in a patient who carries CYP2C19 mutant
地塞米松降低了携带 CYP2C19 突变体的患者的伏立康唑血浆水平
地塞米松降低了携带 CYP2C19 突变体的患者的伏立康唑血浆水平
DOI：
--
发表时间：
2009
期刊：
影响因子：
--
作者：
[Matsumoto K, Kondo T, Kanazawa N, Yokoyama Y, Fukamizu T, Takeda Y, Mukai M, Arimura H, Nakazaki M, Ikawa K, Morikawa N, Tei C, Yamada K]
通讯作者：
Yamada K
Penetration of doripenem into prostatic tissue after intravenous administration in prostatectomy patients
前列腺切除术患者静脉给药后多尼培南对前列腺组织的渗透
前列腺切除术患者静脉给药后多尼培南对前列腺组织的渗透
DOI：
--
发表时间：
2010
期刊：
Int.J.Antimicrob.Agents 35
影响因子：
--
作者：
[Yamada Y, Ikawa K, Nakamura K, Mitsui K, Narushima M, Hibi H, Ikeda K, Morikawa N, Honda N]
通讯作者：
Honda N
DOI：
10.1016/j.ijantimicag.2009.01.008
发表时间：
2009-07-01
期刊：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
影响因子：
10.8
作者：
[Matsumoto, Kazuaki, Ikawa, Kazuro, Yamada, Katsushi]
通讯作者：
Yamada, Katsushi
DOI：
10.1007/s10156-007-0572-1
发表时间：
2008
期刊：
Journal of Infection and Chemotherapy
影响因子：
2.2
作者：
[K. Ikawa;N. Morikawa;K. Ikeda;H. Suyama]
通讯作者：
K. Ikawa;N. Morikawa;K. Ikeda;H. Suyama
共 42 条
Establish the optimal method of administration of the antimicrobial agent was used as an index of treatment goal probability of achieving the target organ and PK / PD theory
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批准号：23590184
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$3.49万
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财政年份：2011
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负责人：MORIKAWA Norifumi
-
依托单位：
海外基金