Clarification of molecular mechanisms how PDLIM2, a nuclear ubiquitin E3 ligase, regulates inflammatory responses

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PDLIM2 negatively regulates inflammatory responses by promoting polyubiquitination and degradation of NF-κB, an essential transcription factor for the inflammation. In this study, we demonstrate that HSP70, a heat shock protein, is essential for PDLIM2-mediated degradation of NF-κB. Moreover, PDLIM2 deficient mice reveal enhanced inflammation and wound healing, which suggests that PDLIM2 negatively regulates both inflammatory and tissue repair responses and prevent the development of chronic inflammatory diseases.