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Physical Chemistry of Lipid-Apolipoprotein Interaction in HDL Biogenesis

Physical Chemistry of Lipid-Apolipoprotein Interaction in HDL Biogenesis
高密度脂蛋白生物发生中脂质-载脂蛋白相互作用的物理化学
批准号:
20790032
负责人:
NAKANO Minoru
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
We investigate apolipoprotein A-I-lipid membrane interaction to elucidate mechanism of the formation of HDLs, which act as anti-atherogenic. We found discoidal lipid-apolipoprotein complexes are spontaneously formed by the change in the lipid compositions and pH at membrane's surface. Structure and lipid dynamics of the discoidal complexes were also evaluated by means of neutron scattering and fluorescence analyses.
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会议论文
Synthetic Pentapeptides Inhibiting Autophosphorylation of Insulin Receptor in a Non-ATP-Competitive Mechanism
合成五肽在非 ATP 竞争机制中抑制胰岛素受体的自磷酸化
DOI: --
发表时间: 2009
期刊: J. Pept. Sci. 15
影响因子: --
作者: [M. Kato, M. Abe, Y. Kuroda, M. Hirose, M. Nakano, T. Handa]
通讯作者: T. Handa
ディスク状脂質/apoA-I複合体の構造と脂質移動速度の評価
圆盘状脂质/apoA-I复合物的结构和脂质转移率的评价
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [S. Morita, Y. Deharu, E. Takata, M. Nakano, T. Handa, 中野実, 伊藤隆, 中野実]
通讯作者: 中野実
DOI: 10.1021/ja9017013
发表时间: 2009-06-17
期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子: 15
作者: [Nakano, Minoru, Fukuda, Masakazu, Handa, Tetsurou]
通讯作者: Handa, Tetsurou
DOI: 10.1021/jp900913w
发表时间: 2009-05-14
期刊: JOURNAL OF PHYSICAL CHEMISTRY B
影响因子: 3.3
作者: [Nakano, Minoru, Fukuda, Masakazu, Handat, Tetsurou]
通讯作者: Handat, Tetsurou
28
    Creation of reaction field on lipid membrane with phospholipid bilayer nanodiscs
    • 批准号:
      25610120
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      NAKANO Minoru
    • 依托单位:
    Structural and Functional Analysis of glycoproteins participating in the mammalian fertilization and development
    • 批准号:
      18570103
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.55万
    • 财政年份:
      2006
    • 负责人:
      NAKANO Minoru
    • 依托单位:
    Structure and Function of Cell Surface Molecules
    • 批准号:
      10045024
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $2.82万
    • 财政年份:
      1998
    • 负责人:
      NAKANO Minoru
    • 依托单位:
    Sperm Receptor of Bovine Egg Surface Zona Pellucida
    • 批准号:
      09680687
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.37万
    • 财政年份:
      1997
    • 负责人:
      NAKANO Minoru
    • 依托单位:
    海外基金