The role of retinoic acid in pituitary tumorigenesis

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The anterior pituitary gland secrets six types of hormones, which are crucial to maintain growth, reproduction, and homeostasis. The purpose of this study is to clarify the relationship between retinoic acid (RA) and tumorigenesis of pituitary. I demonstrated that RA synthesizing enzyme was reduced in estrogen-induced prolactinoma model rats, and that the effect was mediated by estrogen receptor alpha. In addition, RA exerted effects on several genes expression in the anterior pituitary cells. It is hoped that these results contribute to elucidating the neoplasia mechanism and tumor therapy.