The resolution of cerebralvascular disorder by tissue-type plasminogen activor and stromelysin-1
The resolution of cerebralvascular disorder by tissue-type plasminogen activor and stromelysin-1
批准号:
20790204
负责人:
SUZUKI Yasuhiro
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The delayed treatment with tissue-type plasminogen activor (t-PA) on ischemic stroke increases the risk of intracranial bleeding. When we can avoid it, we can save more patients by extending the therapeutic time window. We have found that low density lipoprotein receptor-related protein-1 (LRP-1) is upregulated in endothelial cells by ischemic stress, and the delayed-treated t-PA binds to LRP-1 and induces stromelysin-1 (MMP-3) through the nuclear factor kappa-B (NF-κB) activation. These findings suggest essential pathway for the cerebralvascular disorder by t-PA
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超急性期脳卒中治療におけるアルテプラーゼとプラスミン誘導体との比較:脳梗塞発症後3時間以降における評価
阿替普酶和纤溶酶衍生物治疗超急性脑卒中的比较:脑梗塞发病后3小时后的评估
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[鈴木康裕, 永井信夫, 山川花朱美, 川上純一, Roger Lijnen, 梅村和夫, 鈴木康裕, 鈴木康裕, 鈴木康裕, 鈴木康裕]
通讯作者:
鈴木康裕
薬物による脳出血:tPA治療による脳出血のメカニズムと血管内皮細胞
药物性脑出血:tPA治疗诱发脑出血的机制与血管内皮细胞
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[鈴木康裕, 永井信夫, 山川花朱美, 川上純一, Roger Lijnen, 梅村和夫, 鈴木康裕, 鈴木康裕]
通讯作者:
鈴木康裕
組織型プラスミノゲン活性化因子(t-PA)はリポタンパク質受容体関連タンパクを介してストロメライシン-1(MMP-3)を内皮細胞で誘導する
组织型纤溶酶原激活剂 (t-PA) 通过脂蛋白受体相关蛋白诱导内皮细胞中的基质溶素-1 (MMP-3)。
DOI:
--
发表时间:
2010
期刊:
日本血栓止血学会誌 21巻
影响因子:
--
作者:
[Hong J, Aoyama S, Hirasawa N, Zee O, Ishihara K, Hashida C, Kimura M, Seyama T, Ohuchi K., 鈴木康裕]
通讯作者:
鈴木康裕
光増感反応を用いて脳梗塞巣の大きさを一定にしたマウス病態モデルの確立
利用光敏作用建立脑梗死病灶大小恒定的小鼠病理模型
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[鈴木康裕, 永井信夫, 山川花朱美, 川上純一, Roger Lijnen, 梅村和夫, 鈴木康裕]
通讯作者:
鈴木康裕
超急性期脳卒中治療におけるアルテプラーゼとプラスミン誘導体との比較 : 脳梗塞発症後3時間以降における評価
阿替普酶与纤溶酶衍生物治疗超急性脑卒中的比较:脑梗塞发病后3小时后的评价
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[鈴木康裕, 永井信夫, 山川花朱美, 川上純一, Roger Lijnen, 梅村和夫, 鈴木康裕, 鈴木康裕, 鈴木康裕, 鈴木康裕, 鈴木康裕, 鈴木康裕]
通讯作者:
鈴木康裕
共 9 条
Exploration of the origin of classic Hodgkin lymphoma cells by clonal and genetic analyses
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批准号:21K16279
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项目类别:Grant-in-Aid for Early-Career Scientists
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资助金额:$2.91万
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财政年份:2021
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负责人:SUZUKI Yasuhiro
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依托单位:
Development and validation of innovative impurity transport analysis scheme by extended MHD code
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Analysis of the role of Vasohibi-2 in rhabdomyosarcoma and development of novel cancer therapy
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Male nurses work-family conflict - comparison by gender difference -
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批准号:15K20677
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.16万
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财政年份:2015
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负责人:SUZUKI Yasuhiro
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依托单位:
Implementation of plasma rotation into 3D MHD calculation with stochastic magnetic field and its validation on experiments
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批准号:25420890
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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依托单位:
Disaster-geographic Investigation on the 2011 Great East Japan Earthquake, toward Improving Hazard Estimation Method
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批准号:24240114
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.2万
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财政年份:2012
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负责人:SUZUKI Yasuhiro
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Elucidation of the relevance of bone marrow environment in the onset and exacerbation of allergic rhinitis
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批准号:24791755
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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负责人:SUZUKI Yasuhiro
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依托单位:
Development of high-resolution-DEM stereo-measurement systems and their application to active-fault and tectonic-landform research
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批准号:23650582
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:SUZUKI Yasuhiro
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依托单位:
Role of tissue-type plasminogen activator and matrix metalloproteinase in dementia
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批准号:23790289
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:SUZUKI Yasuhiro
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依托单位:
Tectonic geomorphological studies on prediction of surface rupture patterns associated with active faulting
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资助金额:$12.73万
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依托单位:
Finite Beta Effects on Dynamic Ergodic Divertor
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批准号:20760585
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资助金额:$2.75万
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财政年份:2008
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负责人:SUZUKI Yasuhiro
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依托单位:
Relationship between skeletal muscle carnosine and intense exercise performance.
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批准号:20700534
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资助金额:$2.0万
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财政年份:2008
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负责人:SUZUKI Yasuhiro
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依托单位:
Identification of rice seed phospholipase D null gene and characterization of seed phospholipase D null rice
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批准号:19580008
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资助金额:$3.0万
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Functional analysis of Vasohibin-binding proteins
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Disaster-imageable hazard mapping with adequate usage of geographical informations
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Geomorphological study on the greatest intraplate surface ruptures and their causative active faults in Mongolia
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批准号:18401003
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Screening and characterization of a rice mutant lacking phospholipase D in mature seeds.
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批准号:16580006
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Regulation of phenotype and gene expression in alveolar epithelial cells
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批准号:12670201
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On behaviors of an Abstract Chemistiry
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海外基金