The analysis of Drosophila WNK, the causative gene of PHA2.

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WNK1 and WNK4 have been linked to a hereditary form of human hypertension known as Pseudohypoaldosteronism type II (PHAII). We identified that the malfunction of this regulation caused PHAII in mouse. However, this misregulation cannot cause all of pathological conditions of PHAII, such as a mental retardation, dental abnormalities and impaired growth. We started to look for the other interacting factor(s) of WNK using Drosophila melanogaster, and found the transcription factor, which worked at the downstream of WNK.