Monitoring of neuroinflammation and creation of new strategy after spinal cord injury.

小胶质细胞和巨噬细胞（MG/MF）具有多种功能，依赖于独特的细胞因子刺激，并在中枢神经系统疾病中参与神经细胞死亡、修复和重塑。虽然IL-1已被证明会加剧炎症，但它也被认为会加剧神经变性。我们在IL-1敲除（KO）小鼠的脊髓损伤（SCI）模型中测定了MG/MF的激活表型和IL-1的影响。此外，我们利用成人MG原代培养物证明了IL-1对MG的经典激活和替代激活的贡献。我们在体内实验中证明，IL-1通过减少炎症反应介导的过程抑制了脊髓损伤。此外，我们认为IL-1参与了体内和体外系统中MG的经典激活和替代激活。骨髓间充质干细胞移植到损伤的脊髓中已经被认为可以改善运动功能、神经炎症和再生。

Microglia and macrophages (MG/MF) have a diverse range of functions depending on unique cytokine stimuli, and contribute to neural cell death, repair, and remodeling during central nervous system diseases. While IL-1 has been shown to exacerbate inflammation, it has also been recognized to enhance neurodegeneration. We determined the activating phenotype of MG/MF and the impact of IL-1 in an in vivo spinal cord injury (SCI) model of IL-1 knock-out (KO) mice. Moreover, we demonstrated the contribution of IL-1 to both the classical and alternative activation of MG in vitro using an adult MG primary culture.We demonstrate here in in vivo experiments that IL-1 suppressed SCI in a process mediated by the reduction of inflammatory responses. Moreover, we suggest that IL-1 participates in both the classical and alternative activation of MG in in vivo and in vitro systems. hMSCs Implanted to injured spinal cord have been recognized to improve motor function, neuroinflammation and regeneration.