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Role of the membrane-anchored growth factor in the cell cycle regulation of cancer stem cells

Role of the membrane-anchored growth factor in the cell cycle regulation of cancer stem cells
膜锚定生长因子在癌症干细胞细胞周期调控中的作用
批准号:
20790259
负责人:
FUKUDA Shinji
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
Recent studies suggests that tumors arise from cancer stem cells. Here, we focused on a membrane-anchored growth factor, Amphiregulin (AREG), which is thought to be expressed in side-population (SP) of hepatocyte cell line, Huh7. We identified AREG-regulating protein (ARP), whose expression is also detected in Huh7 SP. ARP promotes the production of soluble AREG (N-terminal fragment of AREG), thus might be involved in the cell cycle regulation of hepatocyte stem cell regulation.
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ADAMによる膜型増殖因子sheddingとcell cycle制御
ADAM 的膜生长因子脱落和细胞周期控制
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakamura T, Ogino H, Kakiuchi S, Hanibuchi M, Nishioka Y, Uehara H, Mitsudomi T, Yatabe Y, Nakamura T, Sone S., Tanuma N, 酒井寿郎, 古川貴久, 福田信治]
通讯作者: 福田信治
DOI: --
发表时间: 2008
期刊: Congenital Anomalies 48
影响因子: --
作者: [Nishida H, Miyagawa S, Matsumaru D, Wada Y, Satoh Y, Ogino Y, Fukuda S, Iguchi T, Yamada G.]
通讯作者: Yamada G.
Ectodomain shedding of EGF family members - the molecular mechanism and the physiological roles-
EGF家族成员的胞外域脱落-分子机制和生理作用-
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [井上博文, 中山寛尚, 上谷晃由, 福田信治, 東山繁樹]
通讯作者: 東山繁樹
膜貫通型増殖因子amphiregulinのshedding制御機構の解析
跨膜生长因子双调蛋白脱落控制机制分析
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [中山寛尚, 福田信治, 井上博文, 東山繁樹]
通讯作者: 東山繁樹
9
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    • 批准号:
      15K03376
    • 项目类别:
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    • 资助金额:
      $2.66万
    • 财政年份:
      2015
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      24658129
    • 项目类别:
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    • 资助金额:
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      24380072
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.56万
    • 财政年份:
      2012
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    • 依托单位:
    海外基金