Identification and assessment of probiotic factor(s) via multiple omics approach.
Identification and assessment of probiotic factor(s) via multiple omics approach.
批准号:
22780132
负责人:
FUKUDA Shinji
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
In order to demonstrate the effect of the bifidobacterial genes encoding 'probiotic transpoter', we generated the genes deficient or overexpressing bifidobacterial strains and assessed them using Escherichia coli O157 : H7 lethal infection murine model. Our experiments clearly showed that the 'probiotic transpoter' largely contributes to the production of acetate by colonized bifidobacteria in the murine colon, and it could prevent the inflammation provoked by Escherichia coli O157 : H7 infection.
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腸管出血性大腸菌O157:H7感染死マウスモデルを用いたビフィズス菌による感染死抑止機構の解明
利用肠出血性大肠杆菌O157:H7感染死亡小鼠模型阐明双歧杆菌抑制感染和死亡的机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[福田真嗣, 藤英博, 長谷耕二, 大島健志朗, 中西裕美子, 吉村和敏, 戸邉亨, 鈴木徹, 伊藤喜久治, 菊地淳, 森田英利, 服部正平, 大野博司, 福田真嗣]
通讯作者:
福田真嗣
Multiple omics identified probiotic bacterial metabolites to prevent gut inflammation provoked by enterohemorrhagic Escherichia coli O157:H7 infection
多个组学鉴定出益生菌代谢物可预防肠出血性大肠杆菌 O157:H7 感染引起的肠道炎症
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Fukuda, S]
通讯作者:
S
難培養微生物研究の最新技術II~ゲノム解析を中心とした最前線と将来展望~第14章微生物群集のメタボローム統合化解析
难培养微生物研究最新技术II——以基因组分析为中心的前沿与未来展望——第14章微生物群落代谢组学综合分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[鳥丸猛, 佐野淳之, 永松大, 戸丸信弘, 西村尚之, 松下通也, 稲永路子, 山本進一, 福田真嗣, 福田真嗣]
通讯作者:
福田真嗣
Acetate producing bifidobacteria equipped with 'probiotic transporters' protects the host against enteropathogenic infection
配备“益生菌转运蛋白”的产乙酸双歧杆菌可保护宿主免受肠道病原感染
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Fukuda, S. and Ohno, H]
通讯作者:
H
マルチオーミクス解析技術を用いた腸内共生システムの理解
利用多组学分析技术了解肠道共生系统
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[斎藤秀之, 山田宰靖, 瀬々潤, 福崎睦美, 清水(稲継)理恵, 清水健太郎, 福田真嗣, 斎藤秀之・山田宰靖・瀬々潤・福崎睦美・清水(稲継)理恵・清水健太郎, 福田真嗣]
通讯作者:
福田真嗣
共 34 条
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批准号:15K03376
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:2015
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依托单位:
Development of fundamental technology for gut ecosystem regulation towards preventive and therapeutic medicine
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批准号:26660118
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2014
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负责人:FUKUDA Shinji
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依托单位:
Construction of novel platform for development of functional food products based on next-generation integrated omics approach
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批准号:24658129
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.66万
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财政年份:2012
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负责人:FUKUDA Shinji
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依托单位:
Exploring the gut microbiota-derived immunomodulation factors
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批准号:24380072
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.56万
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财政年份:2012
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负责人:FUKUDA Shinji
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依托单位:
Role of growth factor and cytokine singaling in the determination of mammary epithelial cell characteristics
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批准号:24590382
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:FUKUDA Shinji
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A Study of Differences between Ricardo Studies in Japan and in the West
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批准号:22530193
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.25万
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财政年份:2010
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负责人:FUKUDA Shinji
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Analysis of the machinery of ectodomain shedding and its possible role for the action of HB-EGF
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批准号:22790319
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资助金额:$2.5万
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财政年份:2010
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Fish habitat evaluation systems considering spatiotemporal dynamics
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批准号:21780225
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财政年份:2009
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依托单位:
Development of an assessment system of probiotics based on host-microbial crosstalk information
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批准号:20780105
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资助金额:$2.75万
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财政年份:2008
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负责人:FUKUDA Shinji
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依托单位:
Role of the membrane-anchored growth factor in the cell cycle regulation of cancer stem cells
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Development of fish habitat preference model using hybrid artificial intelligence techniques
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依托单位:
Examination of the neurological mechanism of grammatical impairment through a linguistic investigation of specific language impairment
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负责人:FUKUDA Shinji
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依托单位:
海外基金