The therapeutic mechanisms of action of kakkonto in a mouse model of food allergy with gastrointestinal symptoms.

在过去的几十年里，食物过敏患者的数量急剧增加。然而，没有有效的药物治疗食物过敏。我的研究结果表明，kakkonto对小鼠食物过敏模型中过敏性腹泻的发展具有治疗作用。过敏性腹泻的发生是由于免疫反应增强和结肠黏膜肥大细胞浸润所致。Kakkonto对增强的免疫应答具有免疫抑制作用，并干扰食物过敏小鼠结肠粘膜肥大细胞的浸润，从而改善过敏症状。此外，转录组分析显示，kakkonto的作用是由于调节T细胞的分化和活化。

The number of patients with food allergy has increased dramatically over the last several decades. However, there is no effective drug for food allergies. My results indicate that kakkonto has therapeutic effects on the development of allergic diarrhea in mouse food allergy model. The development of allergic diarrhea resulted from the enhancement of immune responses and the infiltration of mucosal mast cells in the colon. Kakkonto has immunosuppressive effects on the enhanced immune responses and interferes with the infiltration of mucosal mast cells in the colons of food allergy mouse, leading to improvement of allergic symptoms. Moreover, the transcriptome analyses reveal that the effects of kakkonto is due to the regulation of the differentiation and the activation of T cells.