The effect of kakkonto in allergic immune response mediated by dendritic cells on intestinal mucosal immune system
The effect of kakkonto in allergic immune response mediated by dendritic cells on intestinal mucosal immune system
批准号:
22790616
负责人:
YAMAMOTO Takeshi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Kakkonto, a traditional Japanese herbal medicine, suppressed the occurrence of allergic symptoms in an FA mouse model. Furthermore, Puerariae radix extract and several isoflavones suppressed the occurrence of allergic symptoms in an FA mouse model. The proportion of CD4+Foxp3+regulatory T cells in lamina propria was significantly increased bykakkonto treatment and isoflavones treatment as compared with FA mouse model. Our data suggest that CD4+Foxp3+regulatory T cells induced by kakkonto and isoflavones had suppressive effects on intestinal mucosal immunity in FA mice.
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Shikonin suppresses the activation of mucosal mast cells through the inhibition of nuclear orphan receptors NR4A expression.
紫草素通过抑制核孤儿受体 NR4A 的表达来抑制粘膜肥大细胞的活化。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Hayashi S., Wang X., Umezaki M., Yamamoto T., Kadowaki M.]
通讯作者:
Kadowaki M.
DOI:
10.1248/bpb.33.142
发表时间:
2010-01-01
期刊:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子:
2
作者:
[Kageyama-Yahara, Natsuko, Wang, Ping, Kadowaki, Makoto]
通讯作者:
Kadowaki, Makoto
食物アレルギー病態モデルにおける葛根湯の新規制御性T細胞を介した腸管粘膜免疫抑制作用
Kakkonto 在食物过敏病理模型中的新型调节性 T 细胞介导的肠粘膜免疫抑制作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山本 武, 藤原 加苗, 坪田 悠真, 門脇真]
通讯作者:
門脇真
樹状細胞を介した葛根湯によるエフェクターT細胞の分化・増殖の抑制
Kakkonto 通过树突状细胞抑制效应 T 细胞分化和增殖
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[山本 武, 原優 加, 門脇 真]
通讯作者:
門脇 真
葛根成分および代謝物による食物アレルギー性消化器症状の治療効果
葛根成分及代谢物对食物过敏性胃肠道症状的治疗作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[山本 武, 門脇 真]
通讯作者:
門脇 真
共 9 条
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Development of Helically Chiral Polymers Based on the Condensation of Arylboronic Acids with Diamines
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Effects of interprofessional education on fostering professionalism of health professions students
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Development of novel arrhythmia therapy using K201 binding core in RyR2 molecle
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Corporate mergers, acquisitions and divestitures : Japanese evidences
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Free energy surfaces of chemical reactions in solution and protein environments
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The therapeutic mechanisms of action of kakkonto in a mouse model of food allergy with gastrointestinal symptoms.
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Novel therapeutic strategy of the fatal arrhythmia targeting specific domain in the ryanodine receptor molecle
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Ryanodine receptor as a novel therapeutic target of lethal arrhythmia
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Role of high affinity β-adrenergic receptor, β-arrestin, and β-adrenergic receptor kinase during the development of heart failure
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MACROMOLECULAR ORDERING; MOLECULAR DYNAMICS OF CHAIN FOLDING
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