Novel therapy of arrhythmia targeting key domain in ryanodine receptor
Novel therapy of arrhythmia targeting key domain in ryanodine receptor
批准号:
15K09085
负责人:
YAMAMOTO Takeshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2015
资助国家:
日本
项目状态:
已结题
起止时间:
2015-04-01 至 2018-03-31
中文摘要
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英文摘要
期刊论文(16)
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Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse
R4496C/敲入小鼠中 RyR2 的通道孔突变导致钙渗漏,与 FKBP12.6-RyR2 和钙调蛋白-RyR2 亲和力无关
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Hitoshi Uchinoumi, Ivanita Stefanon, Yi Yang, Mena Said, Xiaoqiong Dong, Rogerio Faustino, Jose L Puglisi, Ye Chen-Izu, Razvan L Cornea, Xander H Wehrens, Wayne S Chen, Takeshi Yamamoto, Yano Masafumi and Donald M Bers]
通讯作者:
Yano Masafumi and Donald M Bers
Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.
钙调蛋白结合域和心脏兰尼碱受体 C 端域之间突变相关的过度紧密相互作用是儿茶酚胺能多形性室性心动过速的新原因。
DOI:
10.1016/j.hrthm.2018.02.006
发表时间:
2018
期刊:
Heart Rhythm
影响因子:
5.5
作者:
[Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M.]
通讯作者:
Yano M.
Stabilization of CaMKII-phosphorylated RyR2 prevents the development of age-related cardiomyopathy caused by transgenic CaMKIIδc overexpression
CaMKII 磷酸化 RyR2 的稳定可预防转基因 CaMKIIδc 过表达引起的年龄相关性心肌病
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, and Masafumi Yano]
通讯作者:
and Masafumi Yano
Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression
Dantrolene 对 Camkii 磷酸化 Ryr2 的稳定可预防由 CamkiiδC 过度表达引起的年龄相关性心肌病的发展
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano]
通讯作者:
Takeshi Yamamoto and Masafumi Yano
High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation is Located at CaM-like Domain of RyR2.
高亲和力CaM而非普通亲和力CaM可以预防CPVT中的心律失常,其突变位于RyR2的CaM样结构域。
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[Nishimura S, Yamamoto T, Fukui G, Maeda T, Hino A, Suetomi T, Ono M, Mochozuki M, Oda T, Okuda S, Kobayashi S, Yano M]
通讯作者:
Yano M
共 14 条
Toward the integration of segment weight and sonority
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批准号:17K02832
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.25万
-
财政年份:2017
-
负责人:YAMAMOTO Takeshi
-
依托单位:
Visions of the End of the Cold War in Europe during the late 1970s
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批准号:25780119
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.25万
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财政年份:2013
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负责人:YAMAMOTO Takeshi
-
依托单位:
A comprehensive study on English syllables
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批准号:25370567
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.25万
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财政年份:2013
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负责人:YAMAMOTO Takeshi
-
依托单位:
Development of Helically Chiral Polymers Based on the Condensation of Arylboronic Acids with Diamines
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批准号:24750105
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$3.0万
-
财政年份:2012
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负责人:YAMAMOTO Takeshi
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依托单位:
Development of novel simulation methods for excited-state reaction dynamics in condensed phases
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批准号:24550022
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.58万
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财政年份:2012
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负责人:YAMAMOTO Takeshi
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依托单位:
Effects of interprofessional education on fostering professionalism of health professions students
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批准号:24590621
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:YAMAMOTO Takeshi
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依托单位:
Development of novel arrhythmia therapy using K201 binding core in RyR2 molecle
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批准号:23591082
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:YAMAMOTO Takeshi
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依托单位:
The effect of kakkonto in allergic immune response mediated by dendritic cells on intestinal mucosal immune system
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批准号:22790616
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2010
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负责人:YAMAMOTO Takeshi
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依托单位:
The effects of onset and coda consonants on syllable quantity
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批准号:22520514
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.83万
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财政年份:2010
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负责人:YAMAMOTO Takeshi
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依托单位:
Development of the object evaluation method of occlusion
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批准号:22791890
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.66万
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财政年份:2010
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负责人:YAMAMOTO Takeshi
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依托单位:
Development and testing of learning materials for improving the risk communication skills of patients and citizens
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批准号:22790487
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2010
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负责人:YAMAMOTO Takeshi
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依托单位:
Corporate mergers, acquisitions and divestitures : Japanese evidences
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批准号:21530307
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2009
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负责人:YAMAMOTO Takeshi
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依托单位:
Free energy surfaces of chemical reactions in solution and protein environments
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批准号:21350010
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2009
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负责人:YAMAMOTO Takeshi
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依托单位:
The therapeutic mechanisms of action of kakkonto in a mouse model of food allergy with gastrointestinal symptoms.
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批准号:20790472
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
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财政年份:2008
-
负责人:YAMAMOTO Takeshi
-
依托单位:
Novel therapeutic strategy of the fatal arrhythmia targeting specific domain in the ryanodine receptor molecle
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批准号:20590868
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2008
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负责人:YAMAMOTO Takeshi
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依托单位:
Ryanodine receptor as a novel therapeutic target of lethal arrhythmia
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批准号:18590777
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.55万
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财政年份:2006
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负责人:YAMAMOTO Takeshi
-
依托单位:
Role of high affinity β-adrenergic receptor, β-arrestin, and β-adrenergic receptor kinase during the development of heart failure
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批准号:12670700
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2000
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负责人:YAMAMOTO Takeshi
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依托单位:
MACROMOLECULAR ORDERING; MOLECULAR DYNAMICS OF CHAIN FOLDING
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批准号:10640371
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1998
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负责人:YAMAMOTO Takeshi
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依托单位:
海外基金