Novel therapy of arrhythmia targeting key domain in ryanodine receptor

针对兰尼碱受体关键域的心律失常新疗法

• 批准号: 15K09085
• 负责人: YAMAMOTO Takeshi
• 金额: $ 3万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09085/
• 关键词: リアノジン受容体; カルモジュリン; 不整脈; E-C coupling; 筋小胞体

项目成果

Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse

R4496C/敲入小鼠中 RyR2 的通道孔突变导致钙渗漏，与 FKBP12.6-RyR2 和钙调蛋白-RyR2 亲和力无关

• 发表时间: 2017
• 作者: Hitoshi Uchinoumi;Ivanita Stefanon;Yi Yang;Mena Said;Xiaoqiong Dong;Rogerio Faustino;Jose L Puglisi;Ye Chen-Izu;Razvan L Cornea;Xander H Wehrens;Wayne S Chen;Takeshi Yamamoto;Yano Masafumi and Donald M Bers
• 通讯作者: Yano Masafumi and Donald M Bers

Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.

钙调蛋白结合域和心脏兰尼碱受体 C 端域之间突变相关的过度紧密相互作用是儿茶酚胺能多形性室性心动过速的新原因。

• DOI: 10.1016/j.hrthm.2018.02.006
• 发表时间: 2018
• 期刊: Heart Rhythm
• 影响因子: 5.5
• 作者: Nishimura S;Yamamoto T;Nakamura Y;Kohno M;Hamada Y;Sufu Y;Fukui G;Nanno T;Ishiguchi H;Kato T;Xu X;Ono M;Oda T;Okuda S;Kobayashi S;Yano M.
• 通讯作者: Yano M.

Stabilization of CaMKII-phosphorylated RyR2 prevents the development of age-related cardiomyopathy caused by transgenic CaMKIIδc overexpression

CaMKII 磷酸化 RyR2 的稳定可预防转基因 CaMKIIδc 过表达引起的年龄相关性心肌病

• 发表时间: 2018
• 作者: Yoko Sufu-Shimizu; Shinichi Okuda; Yoko Okamoto; Shigehiko Nishimura; Takayoshi Kato;Tetsuro Oda; Shigeki Kobayashi; Takeshi Yamamoto;and Masafumi Yano
• 通讯作者: and Masafumi Yano

Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression

Dantrolene 对 Camkii 磷酸化 Ryr2 的稳定可预防由 CamkiiδC 过度表达引起的年龄相关性心肌病的发展

• 发表时间: 2017
• 作者: Yoko S Shimizu;Shinichi Okuda;Yoko Okamoto;Shigehiko Nishimura;Takayoshi Kato;Tetsuro Oda;Shigeki Kobayashi;Takeshi Yamamoto and Masafumi Yano
• 通讯作者: Takeshi Yamamoto and Masafumi Yano

High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation is Located at CaM-like Domain of RyR2.

高亲和力CaM而非普通亲和力CaM可以预防CPVT中的心律失常，其突变位于RyR2的CaM样结构域。

• 发表时间: 2015
• 作者: Nishimura S;Yamamoto T;Fukui G;Maeda T;Hino A;Suetomi T;Ono M;Mochozuki M;Oda T;Okuda S;Kobayashi S;Yano M
• 通讯作者: Yano M