The role of circulating fibrocytes for cardiovascular remodeling

循环纤维细胞在心血管重塑中的作用

• 批准号: 20790540
• 负责人: AMANO Katsuya
• 金额: $ 2.75万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790540/
• 关键词: 分子血管病態学; 心筋線維化

The human peripheral blood contains fibrocytes that can differentiate into other mesenchymal cells, such as myofibroblasts and adipocytes . In this study, we examined the role of fibrocytes in cardiovascular disease. We suggest that fibrocytes are not the critical role in cardiovascular disease such as infracted myocardium, over pressure load and ischemic limb disease in a mouse model.

人外周血含有纤维细胞，其可以分化成其他间充质细胞，如肌成纤维细胞和脂肪细胞。在这项研究中，我们研究了纤维细胞在心血管疾病中的作用。我们认为，在小鼠模型中，纤维细胞不是心血管疾病如心肌梗死、超压负荷和缺血性肢体疾病的关键作用。