Application for pancreatic cancer therapy to develop control method of keratinocyte growth factor signaling pathway by regulation of lumican expression.

在胰腺癌治疗中的应用，开发通过调节lumican表达来控制角质形成细胞生长因子信号通路的方法。

• 批准号: 20790974
• 负责人: YAMAMOTO Tetsushi
• 金额: $ 1.33万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790974/
• 关键词: ケラチノサイト増殖因子; ルミカン; 膵臓癌; ヒト胎児腎細胞; 細胞増殖; プロテオグリカン; ERKシグナル; AKTシグナル

Keratinocyte growth factor (KGF) and its receptor, KGFR play important roles in cell growth and invasion in pancreatic cancer. Administration of recombinant KGF to pancreatic cancer cell lines induced cell growth by does-dependent manner, and it also activated ERK and p38, a member of MAPK. Lumican belongs to the proteoglycan family. When we regulated lumican expression levels in pancreatic cancer cell line, we found that there is a positive correlation between lumican expression levels and cell growth, ERK activation. Proteoglycan plays an important role in stabilizing the binding of KGF and KGFR. Therefore, lumican may regulate pancreatic cancer cell growth to regulate KGF/KGFR signaling pathway.

角质形成细胞生长因子（KGF）及其受体 KGFR 在胰腺癌的细胞生长和侵袭中发挥重要作用。将重组KGF给予胰腺癌细胞系以剂量依赖性方式诱导细胞生长，并且还激活ERK和MAPK成员p38。 Lumican 属于蛋白多糖家族。当我们调控胰腺癌细胞系中lumican的表达水平时，我们发现lumican的表达水平与细胞生长、ERK激活呈正相关。蛋白多糖在稳定 KGF 和 KGFR 的结合中起着重要作用。因此，lumican可能通过调节胰腺癌细胞的生长来调节KGF/KGFR信号通路。

项目成果

膵臓癌の後腹膜浸潤と予後へのlumicanの関与

Lumican参与胰腺癌腹膜后侵袭及预后

• 发表时间: 2009
• 作者: Ishiwata T;et.al.;山本哲志;山本哲志;山本哲志;山本哲志
• 通讯作者: 山本哲志

Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells

• DOI: 10.1016/j.yexmp.2010.01.010
• 发表时间: 2010-06-01
• 期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY
• 影响因子: 3.6
• 作者: Ishiwata, Toshiyuki;Yamamoto, Tetsushi;Naito, Zenya
• 通讯作者: Naito, Zenya

Signal transduction pathway analysis to induce cell growth and vascular endothelial growth factor-A release by keratinocyte growth factor in pancreatic cancer cells

胰腺癌细胞中角化细胞生长因子诱导细胞生长和血管内皮生长因子-A释放的信号转导通路分析

• 发表时间: 2010
• 作者: Ishiwata T;et.al.;山本哲志
• 通讯作者: 山本哲志

小型ロイシンリッチプロテオグリカンlumicanによる膵臓癌の増殖・浸潤への影響

富含亮氨酸的小蛋白聚糖lumican对胰腺癌增殖和侵袭的影响

• 发表时间: 2009
• 作者: Ishiwata T;et.al.;山本哲志;山本哲志;山本哲志;山本哲志;山本哲志;山本哲志
• 通讯作者: 山本哲志

Enhanced expression of lumican correlated with pancreatic cancer cell growth

lumican表达增强与胰腺癌细胞生长相关

• 发表时间: 2010
• 作者: Ishiwata T;et.al.;山本哲志;山本哲志
• 通讯作者: 山本哲志