Repair of meniscus using mesenchymal cells with magnetic targeting method

间充质细胞磁靶向修复半月板

• 批准号: 20791043
• 负责人: YAMASAKI Takuma
• 金额: $ 2.66万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791043/
• 关键词: 移植; 再生医療; 細胞; 組織; 移植・再生医療; 細胞・組織

Efficacy of intraarticular injection of mesenchymal cells (MSC) for meniscus injury was evaluated using MSC-magnetic beads complex in order to improve healing effect on injured meniscus. Firstly, MSC of Sprague-Dawley rats (SD rat) were injected into the knee of SD rats with injured meniscus. Secondary, human MSC were also injected into the knee of nude rats using the same protocol. However, no remarkable increase of extracellular matrices were observed by using the magnetic targeting method in the both models.

为提高半月板损伤的愈合效果，采用骨髓间充质细胞（MSC）-磁珠复合物关节腔内注射治疗半月板损伤。首先，将SD大鼠的MSC注射到半月板损伤的SD大鼠膝关节内。其次，使用相同的方案将人MSC也注射到裸大鼠的膝关节中。然而，通过使用磁靶向方法，在两种模型中均未观察到细胞外基质的显著增加。