Identification of molecular mechanism of excitement with inhalational anesthetics

吸入麻醉药兴奋的分子机制的鉴定

• 批准号: 20791096
• 负责人: YASUI Yutaka
• 金额: $ 2.75万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791096/
• 关键词: 吸入麻酔薬; 青斑核; 興奮; 青斑

The purpose of the present study is to identify the molecular mechanism of the excitement with the inhalational anesthetics. According to the membrane potential recordings of locus coeruleus neurons, it was shown that PKC took part in the excitement of locus coeruleus caused by sevoflurane. Moreover, the behavioral analysis device was made, and the behavior of the rat was expressed numerically. Interestingly, the order in generating inward current for three volatile anesthetics (sevoflurane, isoflurane and halothane), especially the fact that the inward current with sevoflurane was larger than that with halothane, is in complete accord with the behavioral studies showing that sevoflurane provokes the agitation at the strongest in the rat among these anesthetics. The excitatory current activated by sevoflurane in LC neurons might be one of the potential cellular mechanisms underlying paradoxical excitatory effect of sevoflurane.

本研究的目的是确定吸入麻醉药兴奋的分子机制。蓝斑神经元膜电位记录结果表明，PKC参与了七氟醚对蓝斑神经元的兴奋作用。并制作了行为分析装置，对大鼠的行为进行了数值表达。有趣的是，三种挥发性麻醉剂（七氟烷、异氟烷和氟烷）产生内向电流的顺序，特别是七氟烷的内向电流大于氟烷的事实，与行为学研究完全雅阁，表明七氟烷在这些麻醉剂中引起大鼠最强的躁动。七氟醚激活LC神经元的兴奋性电流可能是七氟醚反常兴奋效应的细胞机制之一。

项目成果

Dexmedetomidine Counteracts the Excitatory Effect of Sevoflurane on LC

右美托咪定抵消七氟醚对 LC 的兴奋作用

• 发表时间: 2008
• 作者: K.Kida;Y.Yasui;N.Ohtani;N.Kuratani;E.Masaki.;Yutaka Yasui
• 通讯作者: Yutaka Yasui

Treatment of particle-associated pulmonary aspiration with bronchoscopic lavage : report of two cases

支气管镜灌洗治疗颗粒相关性肺误吸二例报告

• 发表时间: 2009
• 期刊: European journal of anaesthesiology 26
• 作者: Yasui;Y
• 通讯作者: Y

受傷時の呼吸停止から呼吸器離脱に至った高位頚髄損傷の一症例

一例高位颈脊髓损伤导致受伤时呼吸停止并断气的病例。

• 发表时间: 2011
• 作者: 安井豊;藤原千江子;宮崎愛佳;松田祐典;飯田瑠梨;安井豊
• 通讯作者: 安井豊

Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery

下腹部手术患者术中全身右美托咪定和硬膜外新斯的明术后疼痛状况

• 发表时间: 2008
• 期刊: Eur J Anaesthesiol 25
• 作者: Kida K;et.al.
• 通讯作者: et.al.

根津武彦受傷時の呼吸停止から呼吸器離脱に至った高位頚髄損傷の-症例

根津雄彦受伤时高位颈髓损伤导致呼吸停止、呼吸退出一例

• 发表时间: 2011
• 作者: 安井豊;藤原千江子;宮崎愛佳;松田祐典;飯田瑠梨
• 通讯作者: 飯田瑠梨