Eotaxin Immunoreactivity in the Nasal Polyps of Eosinophilic Chronic Rhinosinusitis Patients by using Laser capture microscope

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In the nasal polyps, immunoreactivities of the eotaxin subfamily, eotaxin-1, -2, and -3, were noted in most of the infiltrating eosinophils, as well as in other inflammatory cells, epithelial cells, and endothelial cells. Compared with non-eosinophilic CRS groups, eosinophilic CRS groups had a significant expression of eotaxins in their eosinophils. The eotaxin concentrations of nasal polyp and sinus effusion as measured by ELISA were significantly increased in the eosinophilic CRS group compared to the non-eosinophilic CRS group. By laser capture microdissection, eotaxin-3 alone was amplified from the eosinophil-rich subepithelial tissues.