An analysis of odontoblast differentiation mechanisms by using dental pulp SP cells

虽然许多研究表明，许多转录因子参与成牙本质细胞的分化，但成牙本质细胞分化的具体因素仍不清楚。在本研究中，SUMO蛋白和Osterix的免疫组织化学定位在未成熟的成牙本质细胞中可见;然而，这些免疫反应性在成熟的成牙本质细胞中减少。这些结果表明SUMO蛋白和Osterix在成熟成牙本质细胞中的表达降低可能是牙本质形成所必需的。

Although a number of studies suggest that many transcription factors participate in odontoblast differentiation, specific factors of odontoblast differentiation are still unknown. In the present study, immunohistochemical localizations for SUMO proteins and Osterix were visible in the immature odontoblasts ; however these immunoreactivities were reduced in the mature odontoblasts. These results demonstrate that reduction of expressions for SUMO proteins and Osterix in the mature odontoblasts might be necessary for dentin formation.