权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Bioactivation of titanium using calcium-hydroxide slurry

使用氢氧化钙浆料对钛进行生物活化

基本信息

批准号：
20791460
负责人：
OHTSU Naofumi
金额：
$ 2.58万
依托单位：
Kitami Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

项目摘要

The activation of osteogenesis on titanium has been a major interest for biomaterial researchers, and, thus, various surface modification techniques have been studied. Among these techniques, a hydroxyapatite (HAP) coating applied by the plasma-splaying process is the most successful technique due to its good biomaterial-bone fixation ability and HAP-coated titanium is currently used in clinical settings. However, dentists and orthopedists have pointed out that fracture at the HAP-titanium interface and dissolution of the coating itself sometimes occur after such implants have been in the human body for a long time. We recently developed a chemical coating technique using calcium-hydroxide slurry. The process is as follows: a titanium substrate is buried in calcium-hydroxide slurry prepared by a mixture of calcium-hydroxide powder with water, and, subsequently, the slurry containing the titanium substrate is heated in air. We revealed that, by treating a titanium plate with this proces … More s, a calcium titanate coating was formed on its surface. In the present study, the relationships between the treatment conditions and the characteristics of the surface layer were investigated. Furthermore, the surface-modified titanium rod was surgically inserted in hard tissue of rat, and osteogenesis around the rod was investigated.We initially investigated the effect of heating temperatures in the slurry processing upon characteristics of the coatings. When using the heating temperature beyond 600℃, a crystallized calcium titanate coating was formed on its surface, and the coated titanium can precipitate calcium phosphate in a simulated body fluid rapidly. When raising the temperature, thick titanium dioxide layer was simultaneously formed on the substrate, resulting in the decrease of the adhesion strength of the coating. We secondly attempted to improve biocompatibility of the coating by adding sodium ions in the slurry. When preparing the slurry by mixing Ca(OH)_2 with 1-M NaOH or NaCl solutions, a composite coating comprising calcium and sodium titanates were formed on the substrate. The composite coating could precipitate calcium phosphate more rapidly, although mechanical strength of the coating would decrease owing to the formation of the thick coating. Last, we surgically implanted the Ti rod treated with the Ca(OH)_2 slurry and with the heating temperature of 600℃, into a rat. At 7 days, new bone was formed vigorously and was in contact with the surface directly. Less

钛表面的成骨活化一直是生物材料研究人员的主要兴趣，因此，各种表面改性技术已经被研究。其中，等离子喷涂羟基磷灰石(HAP)涂层技术因其良好的生物材料-骨固定能力是最成功的技术，而HAP涂层钛目前正在临床上应用。然而，牙医和骨科医生指出，在这种植入物在人体内放置很长一段时间后，有时会发生HAP-钛界面的断裂和涂层本身的溶解。我们最近开发了一种使用氢氧化钙浆料的化学涂层技术。该方法如下：将钛衬底埋入由氢氧化钙粉末和水的混合物制备的氢氧化钙浆料中，然后，在空气中加热含有钛衬底的浆料。我们发现，通过使用这种工艺…处理钛板再加上S，表面形成了一层钛酸钙涂层。在本研究中，研究了处理条件与表面层特性之间的关系。在此基础上，将表面修饰后的钛棒植入大鼠的硬组织内，研究了钛棒周围的成骨情况，初步探讨了浆料加工中加热温度对涂层性能的影响。当加热温度超过600℃时，钛表面形成了一层结晶的钛酸钙涂层，涂层钛能在模拟体液中快速沉淀磷酸钙。随着温度的升高，涂层表面同时形成较厚的二氧化钛涂层，导致涂层结合强度下降。其次，我们尝试通过在浆料中添加钠离子来改善涂层的生物相容性。当将氢氧化钙与1-M氢氧化钠或氯化钠溶液混合制备浆料时，在基材上形成了一层由钙和钛酸钠组成的复合涂层。复合涂层可以更快地析出磷酸钙，但涂层的机械强度会因为涂层较厚而降低。最后，我们将经Ca(OH)_2浆液处理、加热温度为600℃的钛棒植入大鼠体内。7d时，新骨形成旺盛，与表面直接接触。较少