Clinical trial of Spinal Cord Regeneration Treatment by Transplanting Olfactory Ensheathing Cells (OECs) in Dogs

点击翻译按钮获取中文摘要

The purpose of this study was a clinical trial of nasal mucosa derived OECs transplantation therapy to regenerate the function of the spinal cord in the clinical cases of dogs with paraplegia due to spinal cord injury. However I could not apply the therapy to any case because the owner of dogs did not agree with this clinical trial, although there were many dogs which could become candidate. Therefore I established new method to harvest the olfactory mucosa without craniotomy by endoscopic biopsy via nasal cavity. In addition I studied electrophysiological examination using extradural catheter electrode in dogs to select cases for cell transplantation therapy and to decide the efficacy of the therapy.