Novel neuroprotectant lithium in thrombolytic therapy
Novel neuroprotectant lithium in thrombolytic therapy
批准号:
20890072
负责人:
TAKAHASHI Tetsuya
金额:
$1.87万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (Start-up)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
脳梗塞に対する新規神経保護薬リチウムの組織プラスミノーゲン・アクチベーター(t-PA)との併用療法について検討するため、よりヒトに近い動物モデルの確立を行った。種々の条件を検討した結果として、t-PAにより血栓溶解を起こし脳虚血の改善が得られ、かつ脳虚血からある程度の時間が経過した場合には逆に脳出血を含めたt-PAの副作用により脳虚血性障害が増悪する、といったヒトでの脳塞栓に近い状態をできるだけ再現することに成功した。このような臨床に即した動物モデルは望まれているものの手技上の難しさから未だ使われる報告は少ない。今後このモデルを使いリチウムの治療効果を検討する。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Changes in protein levels of phosphorylated Akt and GSK 3 beta may not contribute to the protection of Lithium against focal ischemia in rats
磷酸化 Akt 和 GSK 3 beta 蛋白质水平的变化可能无助于锂对大鼠局灶性缺血的保护作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[笹野哲郎, 古川哲史, 磯部光章, 笹野哲郎, 笹野 哲郎, Satoshi Sasaki, Satoshi Sasaki, 佐々木 諭, 高橋哲哉]
通讯作者:
高橋哲哉
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依托单位:
海外基金