Novel neuroprotectant lithium in thrombolytic therapy

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To investigate the neuroprotective effect of lithium with tissue plasminogen activator(t-PA) in thrombolytic therapy in stroke, I tried to establish the clinically-resembling animal stroke model. After several experimental condition had been tried, I've established the model that showed thrombolysis and neurological improvement by t-PA administration in early time point, and also showed worsened outcome including increased hemorrhage by t-PA administration in late time point. Similar animal model is not used in many reports because of the technical difficulty. Administration of lithium chloride after focal brain ischemia suppressed neurodegeneration through apoptosis. This protective effect was not related the activation of Akt.