Possible involvement of CD45^+/collagen I^+ dual positive cells in renal fibrosis and cardiorenal syndrome.
Possible involvement of CD45^+/collagen I^+ dual positive cells in renal fibrosis and cardiorenal syndrome.
批准号:
20590952
负责人:
WADA Takashi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
CD45^<+/>Collagen I^+ dual positive cells migrate into fibrotic kidney dependent on chemokine system, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating renal fibrosis. In addition, our present data suggest the possible involvement of CD45^+/Collagen I^+ dual positive cells in cardiac fibrosis, closely related to renal lesions. Furthermore, the detection of CD45^+/Collagen I^+ dual positive cells in circulation has been established in this study.
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Chemokine/chemokine receptor-mediated inflammation regulates pathogenic changes from acute kidney injury to chronic kidney disease
趋化因子/趋化因子受体介导的炎症调节从急性肾损伤到慢性肾病的致病变化
DOI:
--
发表时间:
2009
期刊:
Clin Exp Nephrol 13
影响因子:
--
作者:
[Furuichi K, Kaneko S, Wada T]
通讯作者:
Wada T
腎線維化にはたす骨髄由来細胞の意義
骨髓来源细胞在肾纤维化中的意义
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[K.Mori, et al., 柳田素子, 和田隆志]
通讯作者:
和田隆志
Fibrocyte and Renal Injury
纤维细胞和肾损伤
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[H.Imamaki, K.Mori, et al., 和田隆志]
通讯作者:
和田隆志
DOI:
10.1097/hjh.0b013e3282f3e9e6
发表时间:
2008-04-01
期刊:
JOURNAL OF HYPERTENSION
影响因子:
4.9
作者:
[Sakai, Norihiko, Wada, Takashi, Kaneko, Shuichi]
通讯作者:
Kaneko, Shuichi
DOI:
10.1016/j.humpath.2009.10.008
发表时间:
2010-05-01
期刊:
HUMAN PATHOLOGY
影响因子:
3.3
作者:
[Sakai, Norihiko, Furuichi, Kengo, Wada, Takashi]
通讯作者:
Wada, Takashi
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