Studies on the pathogenesis of autoimmune thyroid diseases : using genetically-engineered mice
Studies on the pathogenesis of autoimmune thyroid diseases : using genetically-engineered mice
批准号:
20591099
负责人:
NAGAYAMA Yuji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To scrutinize the pathogenesis of autoimmune thyroid diseases (Graves' disease and Hashimoto' thyroiditis) using genetically-engineered mice.
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Enhanced response to mouse thyrotropin (TSH) receptor immunization in TSH knockout mice.
TSH 敲除小鼠对小鼠促甲状腺素 (TSH) 受体免疫的反应增强。
DOI:
--
发表时间:
2010
期刊:
Endocrinology. 151(8)
影响因子:
--
作者:
[Nakahara M, Mitsutake N, Sakamoto H, Ichiakwa T, Abiru N, Chen C-R, Rapoport B, McLachlan SM, Nagayama Y.]
通讯作者:
Nagayama Y.
Attenuation of induced hyperthyroidism in mice by pre-treatment with thyrotropin receptor protein : diversion of thyroid stimulating antibody to non-functional antibody induction.
通过用促甲状腺素受体蛋白预处理减轻小鼠诱发的甲状腺功能亢进症:将促甲状腺抗体转向非功能性抗体诱导。
DOI:
--
发表时间:
2009
期刊:
Endocrinology. 150(8)
影响因子:
--
作者:
[Misharin AV, Nagayama Y, Holly A. Aliesky AH, Mizutori Y, Rapoport B, McLachlan SM.]
通讯作者:
McLachlan SM.
Fibroblast- mediated in vivo and in vitro growth promotion of thyroid carcinoma FTRL-Tc, not normal thyroid FRTL5, cells.
成纤维细胞介导的甲状腺癌 FTRL-Tc(而非正常甲状腺 FRTL5)细胞的体内和体外生长促进。
DOI:
--
发表时间:
2009
期刊:
Thyroid. 19(7)
影响因子:
--
作者:
[Saitoh O, Mitsutake N, Nakayama T, Nagayama Y.]
通讯作者:
Nagayama Y.
Exacerbation of autoimmune thyroiditis by a single dose of whole body irradiation in NOD-H2h4 mice.
NOD-H2h4 小鼠单剂量全身照射导致自身免疫性甲状腺炎恶化。
DOI:
--
发表时间:
2008
期刊:
Int J Radiat Biol. 84(9)
影响因子:
--
作者:
[Nagayama Y, Kaminoda K, Mizutori Y, Saitoh O, Abiru N.]
通讯作者:
Abiru N.
DOI:
10.3109/08916934.2010.548839
发表时间:
2011-09-01
期刊:
AUTOIMMUNITY
影响因子:
3.5
作者:
[Nakahara, Mami, Nagayama, Yuji, Abiru, Norio]
通讯作者:
Abiru, Norio
共 49 条
Studies on thyorid cancer pathogenesis using mouse models
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批准号:19K09028
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2019
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负责人:NAGAYAMA Yuji
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依托单位:
Studies on thyroid autoimmunity: anti-mouse TSH receptor immune response and central tolerance in mice
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批准号:15K09437
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2015
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负责人:NAGAYAMA Yuji
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依托单位:
Studies on thyroid autoimmunity: anti-TSHR immune response and tolerance in mice
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批准号:24591368
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:NAGAYAMA Yuji
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依托单位:
Studies on the pathogenesis of Graves' disease and new treatment using our recently established mouse model.
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批准号:17590965
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:NAGAYAMA Yuji
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依托单位:
Studies on the poathogenesis of Graves' disease and new treatment using our recently established mouse model.
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批准号:14571069
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2002
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负责人:NAGAYAMA Yuji
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依托单位:
Evaluation of the therapeutic effect of replication-competent adenovirus on thyroid carcinomas
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批准号:12671090
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:NAGAYAMA Yuji
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依托单位:
Studies on structure-function of the thyrotropin receptor : molecular biological analysis of post-translational modifications
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批准号:09671064
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
-
负责人:NAGAYAMA Yuji
-
依托单位:
海外基金