Studies on the pathogenesis of autoimmune thyroid diseases : using genetically-engineered mice

自身免疫性甲状腺疾病发病机制的研究：利用基因工程小鼠

• 批准号: 20591099
• 负责人: NAGAYAMA Yuji
• 金额: $ 3万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591099/
• 关键词: 甲状腺自己免疫; TSH受容体; 橋本病; バセドウ病

To scrutinize the pathogenesis of autoimmune thyroid diseases (Graves' disease and Hashimoto' thyroiditis) using genetically-engineered mice.

利用基因工程小鼠研究自身免疫性甲状腺疾病（Graves病和桥本甲状腺炎）的发病机制。

项目成果

Enhanced response to mouse thyrotropin (TSH) receptor immunization in TSH knockout mice.

TSH 敲除小鼠对小鼠促甲状腺素 (TSH) 受体免疫的反应增强。

• 发表时间: 2010
• 期刊: Endocrinology. 151(8)
• 作者: Nakahara M;Mitsutake N;Sakamoto H;Ichiakwa T;Abiru N;Chen C-R;Rapoport B;McLachlan SM;Nagayama Y.
• 通讯作者: Nagayama Y.

Attenuation of induced hyperthyroidism in mice by pre-treatment with thyrotropin receptor protein : diversion of thyroid stimulating antibody to non-functional antibody induction.

通过用促甲状腺素受体蛋白预处理减轻小鼠诱发的甲状腺功能亢进症：将促甲状腺抗体转向非功能性抗体诱导。

• 发表时间: 2009
• 期刊: Endocrinology. 150(8)
• 作者: Misharin AV;Nagayama Y;Holly A. Aliesky AH;Mizutori Y;Rapoport B;McLachlan SM.
• 通讯作者: McLachlan SM.

Fibroblast- mediated in vivo and in vitro growth promotion of thyroid carcinoma FTRL-Tc, not normal thyroid FRTL5, cells.

成纤维细胞介导的甲状腺癌 FTRL-Tc（而非正常甲状腺 FRTL5）细胞的体内和体外生长促进。

• 发表时间: 2009
• 期刊: Thyroid. 19(7)
• 作者: Saitoh O;Mitsutake N;Nakayama T;Nagayama Y.
• 通讯作者: Nagayama Y.

Exacerbation of autoimmune thyroiditis by a single dose of whole body irradiation in NOD-H2h4 mice.

NOD-H2h4 小鼠单剂量全身照射导致自身免疫性甲状腺炎恶化。

• 发表时间: 2008
• 期刊: Int J Radiat Biol. 84(9)
• 作者: Nagayama Y;Kaminoda K;Mizutori Y;Saitoh O;Abiru N.
• 通讯作者: Abiru N.

The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages

• DOI: 10.3109/08916934.2010.548839
• 发表时间: 2011-09-01
• 期刊: AUTOIMMUNITY
• 影响因子: 3.5
• 作者: Nakahara, Mami;Nagayama, Yuji;Abiru, Norio
• 通讯作者: Abiru, Norio