The role of Toll-like receptor signaling in wound healing

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Although Toll-like Receptor (TLR) plays an important role in innate immunity, its role in wound healing has yet to be analyzed. In the present study, the healing process of dermal wounds in TLR knock-out mice was examined. No significant findings were observed in Myd88 KO mice. Meanwhile, PDLIM2 KO mice, which showed exaggerated NF-κB activity, demonstrated earlier wound closure due to enhanced wound contraction. Contraction of the collagen gel seeded with fibroblasts from KO mice was also enhanced, suggesting the involvement of TLR signaling in wound healing.