The role of Toll-like receptor signaling in wound healing

尽管Toll样受体（TLR）在先天免疫中起重要作用，但其在伤口愈合中的作用还有待分析。在本研究中，检查TLR基因敲除小鼠皮肤伤口的愈合过程。在Myd 88 KO小鼠中未观察到显著发现。同时，PDLIM 2基因敲除小鼠的NF-κB活性增强，由于伤口收缩增强，伤口闭合较早。接种有来自KO小鼠的成纤维细胞的胶原凝胶的收缩也增强，表明TLR信号传导参与伤口愈合。

Although Toll-like Receptor (TLR) plays an important role in innate immunity, its role in wound healing has yet to be analyzed. In the present study, the healing process of dermal wounds in TLR knock-out mice was examined. No significant findings were observed in Myd88 KO mice. Meanwhile, PDLIM2 KO mice, which showed exaggerated NF-κB activity, demonstrated earlier wound closure due to enhanced wound contraction. Contraction of the collagen gel seeded with fibroblasts from KO mice was also enhanced, suggesting the involvement of TLR signaling in wound healing.