Role of obestatin in anxiety disorders

胃分泌胃饥饿素，大脑也分泌胃饥饿素。胃饥饿素与抑郁、焦虑和饮食行为有关。GPR 39是生长激素释放肽的受体。我们研究了肥胖抑制素、抑郁、焦虑和饮食行为之间的关系。将GPR 39 -1b反义寡核苷酸以恒定速率注入大鼠侧脑室，并监测其对焦虑和食物摄入的影响。GPR 39 -1b反义寡核苷酸在高架十字迷宫试验以及黑色和白色试验中产生抗焦虑样作用。GPR 39 -1b反义寡核苷酸减少摄食量。这些结果表明，GPR 39 -1b的抑制诱导焦虑相关行为的减少并扰乱食欲。

Stomach secretes ghrelin, and brain also doses it. Ghrelin have reported to be associated with depression, anxiety and eating behavior. GPR39 is a receptor for ghrelin. We examined the relationship between obestatin, depression, anxiety and eating behavior. We GPR39-1b antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety and food intake was monitored. GPR39-1b antisense oligonucleotides produced anxiolytic-like effects in the elevated-plus maze test, and in the black and white test. GPR39-1b antisense oligonucleotides decreased food intake. These results indicate that inhibition of GPR39-1b induces a decrease in anxiety-related behaviors and disturbs appetite.