ANXIETY STUDY BY USING HGF TRANSGENICMICE

使用 HGF 转基因小鼠进行焦虑研究

• 批准号: 15591232
• 负责人: AKIYOSHI Jotaro
• 金额: $ 2.18万
• 依托单位: OITA UNIVERSITY (2004)大分医科大学 (2003)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591232/
• 关键词: HGF; ANXIETY; TRANSJENICMICE

BACKGROUND : Hepatocyte growth factor(HGF) has the capacity to selectively direct thalamocortical projections into an intermediate target, the pallidum, and eventually to their final cortical destination. HGF may have a role in the mediation of anxiety. Very little is known about other central behavioral effects of HGF. OBJECTIVE : Our aim was to determine what effect HGF has on anxiety in rats. METHODS : HGF was infused at a constant rate into cerebral lateral ventricles and its effect on anxiety in rats was monitored. RESULTS : In the elevated plus maze test and the black and white box test, HGF administration caused all indicators of anxiety to increase. No significant effect on general locomotor activity was seen. CONCLUSION : HGF infusion into the brain produces an anxiolytic effect.

背景：肝细胞生长因子（HGF）具有选择性地引导丘脑皮质投射到中间靶点——苍白球，并最终到达最终的皮层目的地的能力。HGF可能在焦虑的调解中起作用。我们对HGF的其他核心行为影响知之甚少。目的：我们的目的是确定HGF对大鼠焦虑的影响。方法：恒速脑侧脑室注入HGF，观察其对大鼠焦虑的影响。结果：在升高+迷宫试验和黑白盒试验中，HGF给药使焦虑各指标均升高。一般运动活动未见明显影响。结论：HGF脑内灌注具有抗焦虑作用。

项目成果

Anxiolytic effect of hepatocyte growth factor infused into rat brain.

肝细胞生长因子注入大鼠脑的抗焦虑作用。

• 发表时间: 2005
• 期刊: Neuropsychobiology 51
• 作者: Okunishi;K. et al.;Shigemura N. et al.;Fujiwara H. et al.;Futamatsu H. et al.;Murakami M. et al.;Shigemura N. et al.;Ito W.et al.;Isogawa K. et al.
• 通讯作者: Isogawa K. et al.