Underlying cause of a patient elucidation and clinica application of the panic disorder

患者惊恐障碍的根本原因解析及临床应用

• 批准号: 18591296
• 负责人: AKIYOSHI Jotaro
• 金额: $ 2.48万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591296/
• 关键词: Panic Disorder; Anxiety; Hepatocvte Growth Factor; Ghrelin; Serotonin; GABA; NIRS; ラット; 遺伝子多型; 機能的MRI

We investigated basic and clinical research for panic disorder Hist, we examine associate genetic study We could not find the relationship between ghrelin, serotonin receptor 3, mGluR7, mGluRS, GABA receptor alfa-6 subunit, nociceptine/orphanin FQ receptor and panic disorder Second, we examine the role of hepatocyte growth fector (HGF) and ghrelin in animal model of anxiety We injected the antisense of these substances to rafe lateral ventricle by using mini pump. The inhibition of HGF induces an increase in depression and anxiety-related behaviors. HGF might have antidepressive and anxiolytic effect. Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats. Third, we examine human frontal cortex in healthy volunteers by using near-infrared reflection spectroscopy (NIRS) prior to and during anticipatory anxiety to determine if NIRS could detect any anxiety-related changes. O2Hb levels in the right frontal region correlate with anxiety or heightened negative effect.

我们调查了惊恐障碍的基础和临床研究Hist，我们检查了相关的遗传学研究，我们没有发现ghrelin，5-羟色胺受体3，mGluR 7，mGluRS，GABA受体α-6亚基，FQ受体中的痛敏素/痛敏素与惊恐障碍的关系。我们研究了肝细胞生长因子（HGF）用微型泵将上述物质的反义核酸注入rafe侧脑室。HGF的抑制诱导抑郁和焦虑相关行为的增加。HGF可能具有抗抑郁和抗焦虑作用。Ghrelin反义DNA的管理引起大鼠的抗抑郁和抗焦虑反应。第三，我们研究人类额叶皮层健康志愿者使用近红外反射光谱（NIRS）之前和期间预期焦虑，以确定NIRS是否可以检测到任何焦虑相关的变化。右额区的O2 Hb水平与焦虑或负面影响加剧有关。

项目成果

Biologic base of anxiety disorders : recent progress

焦虑症的生物学基础：最新进展

• 发表时间: 2007
• 期刊: Nihon Shinkei Seishin Yakurigaku Zasshi 27(2)
• 作者: Isogawa;K.;Akiyoshi;J.
• 通讯作者: J.

Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder.

血清素受体 3A (HTR3A) 基因与人格特质相关，但与恐慌症无关。

• 发表时间: 2008
• 期刊: Psychiatric Genetics 18
• 作者: Mizuta N;Akiyoshi J;et al.
• 通讯作者: et al.

Biologic base of anxiety disorders:recent progress.Nihon Shinkei Seishin Yakurigaku Zasshi

焦虑症的生物学基础：最新进展.Nihon Shinkei Seishin Yakurigaku Zasshi

• 发表时间: 2007
• 期刊: Psychiatr Genet. 27(2)
• 作者: Isogawa K;Akiyoshi J.
• 通讯作者: Akiyoshi J.

Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.

• DOI: 10.1097/ypg.0b013e32801118bc
• 发表时间: 2007-02
• 期刊: Psychiatric genetics
• 影响因子: 0.9
• 作者: Y. Kobayashi;J. Akiyoshi;Masayuki Kanehisa;Shugo Ichioka;Yoshihiro Tanaka;Jusen Tsuru;Hiroaki Hanada;K. Kodama;K. Isogawa;T. Tsutsumi

Serotonin receptor 3A(HTR3A)gene is associated with personality traits

血清素受体3A(HTR3A)基因与人格特质相关

• 发表时间: 2008
• 期刊: Psychiatr Genet. 18(1)
• 作者: Mizuta N;et. al.
• 通讯作者: et. al.