Underlying cause of a patient elucidation and clinica application of the panic disorder

我们调查了惊恐障碍HIST的基础和临床研究，我们进行了相关的遗传学研究，我们没有发现Ghrelin、5-羟色胺受体3、mGluR7、mGluRs、GABA受体α-6亚单位、伤害素/孤儿FQ受体与惊恐障碍的关系。其次，我们研究了肝细胞生长因子(HGF)和Ghrelin在焦虑动物模型中的作用。抑制HGF会导致抑郁和焦虑相关行为的增加。HGF可能具有抗抑郁、抗焦虑作用。给予Ghrelin的反义DNA可引起大鼠的抗抑郁和缓解焦虑反应。第三，我们通过使用近红外反射光谱(NIRS)检测健康志愿者在预期焦虑之前和期间的额叶皮质，以确定NIRS是否可以检测到任何与焦虑相关的变化。右侧额叶的O2Hb水平与焦虑或增强的负面影响相关。

We investigated basic and clinical research for panic disorder Hist, we examine associate genetic study We could not find the relationship between ghrelin, serotonin receptor 3, mGluR7, mGluRS, GABA receptor alfa-6 subunit, nociceptine/orphanin FQ receptor and panic disorder Second, we examine the role of hepatocyte growth fector (HGF) and ghrelin in animal model of anxiety We injected the antisense of these substances to rafe lateral ventricle by using mini pump. The inhibition of HGF induces an increase in depression and anxiety-related behaviors. HGF might have antidepressive and anxiolytic effect. Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats. Third, we examine human frontal cortex in healthy volunteers by using near-infrared reflection spectroscopy (NIRS) prior to and during anticipatory anxiety to determine if NIRS could detect any anxiety-related changes. O2Hb levels in the right frontal region correlate with anxiety or heightened negative effect.