transcranial magnetic stimulation induced animal model anxiety

重复经颅磁刺激(RTMS)已被证明对情感障碍和焦虑症有治疗作用。然而，一些报告将rTMS与正常志愿者焦虑的显著增加联系在一起。本研究调查了rTMS对焦虑的影响，以及在这种焦虑的动物模型上使用急慢性帕罗西汀治疗的情况。在正常大鼠，rTMS连续10天可引起焦虑，如高架迷宫、黑白盒和条件性恐惧试验。这种焦虑可被慢性帕罗西汀、急性安定、阿普唑仑和丁螺环酮抑制，但不能被急性帕罗西汀治疗。这些结果表明，接受长期rTMS治疗的比率可以作为焦虑的模型，rTMS引起的焦虑可能涉及5-羟色胺能系统和GABA系统。

Repetitive transcranial magnetic stimulation (rTMS) has been shown to have a therapeutic effect on affective disorder and anxiety disorders. However, some reports have linked rTMS to a significant increase in anxiety in normal volunteers. This study investigated the effect of rTMS on anxiety and the use of acute and chronic paroxetine treatment on this animal model of anxiety. In normal rats, rTMS for 10 days induced anxiety, as shown by elevated plus maze, black and white box, and conditioned fear tests. This anxiety was suppressed by chronic paroxetine, acute diazepam, alprazolam and buspirone but not acute paroxetine treatment. These results suggest that rate receiving chronic rTMS treatment can be used as a model of anxiety and that the anxiety induced by rTMS might involve the serotonergic and GABA system.