Study for FKBP5 and CRHR1 in depression and panic disorder

CRHR1和FKBP5基因也与抑郁症和惊恐障碍相关。这些基因多态性被发现与焦虑有关。FKBP5基因多态性与额叶和杏仁核的VBM显著相关。应激相关的CRHR1基因和FKBP5基因与抑郁和惊恐障碍相关。我们的研究结果表明，FKBP5单核苷酸多态性，唾液皮质醇和唾液淀粉酶反应之间存在显着的相互作用，在三个水平的调节。唾液皮质醇和淀粉酶反应与FKBP5显著相关。脑容量也可能受到这些基因的影响。

CRHR1 and FKBP5 gene were also found an association with depression and panic disorder. These genetic polymorphisms were found to be associated with anxiety. The context of FKBP5 gene polymorphism was significantly related to the VBM of frontal lobe and amygdala. CRHR1 genes and FKBP5 related to the stress were associated with depression and panic disorder. Our results showed that a significant interaction exists between FKBP5 SNPs, salivary cortisol and salivary amylase responses at three levels of regulation. Salivary cortisol and amylase responses were significantly associated with FKBP5. The brain volume could be also affected by these genes.