Study for FKBP5 and CRHR1 in depression and panic disorder

FKBP5 和 CRHR1 在抑郁症和恐慌症中的研究

• 批准号: 23591719
• 负责人: AKIYOSHI Jotaro
• 金额: $ 3.24万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591719/
• 关键词: FKBP5; CRHR1; ストレス; 唾液アミラーゼ; 唾液コルチゾール; 遺伝子; PCR; うつ病; パニック障害; 大うつ病性障害

CRHR1 and FKBP5 gene were also found an association with depression and panic disorder. These genetic polymorphisms were found to be associated with anxiety. The context of FKBP5 gene polymorphism was significantly related to the VBM of frontal lobe and amygdala. CRHR1 genes and FKBP5 related to the stress were associated with depression and panic disorder. Our results showed that a significant interaction exists between FKBP5 SNPs, salivary cortisol and salivary amylase responses at three levels of regulation. Salivary cortisol and amylase responses were significantly associated with FKBP5. The brain volume could be also affected by these genes.

CRHR1和FKBP5基因也与抑郁症和惊恐障碍相关。这些基因多态性被发现与焦虑有关。FKBP5基因多态性与额叶和杏仁核的VBM显著相关。应激相关的CRHR1基因和FKBP5基因与抑郁和惊恐障碍相关。我们的研究结果表明，FKBP5单核苷酸多态性，唾液皮质醇和唾液淀粉酶反应之间存在显着的相互作用，在三个水平的调节。唾液皮质醇和淀粉酶反应与FKBP5显著相关。脑容量也可能受到这些基因的影响。

项目成果

The thyrotropin-releasing hormone test may predict recurrence of clinical depression within ten years after discharge.

• 发表时间: 2013
• 期刊: Neuro endocrinology letters
• 作者: Jusen Tsuru;Yoshinobu Ishitobi;Taiga Ninomiya;Masayuki Kanehisa;Junko Imanaga;Ayako Inoue;Shizuko Okamoto;Yoshihiro Maruyama;Haruka Higuma;Yoshihiro Tanaka;Hiroaki Hanada;K. Isogawa;J. Akiyoshi

Hippocampal agenesis in an individual who engaged in violent criminal behaviors after discontinuing carbamazepine and paroxetine treatment.

停止卡马西平和帕罗西汀治疗后从事暴力犯罪行为的个体海马发育不全。

• DOI: 10.1111/j.1556-4029.2012.02248.x
• 发表时间: 2013
• 期刊: Journal of forensic sciences
• 影响因子: 1.6
• 作者: Hiroaki Hanada;Jotaro Akiyoshi;Masayuki Kanehisa;Yoshinobu Ishitobi;Jusen Tsuru;Yoshihiro Tanaka;Tsuyoshi Shimomura;Yoshihisa Kawano.
• 通讯作者: Yoshihisa Kawano.

Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in patients with the generalized type of social anxiety disorder.

广泛型社交焦虑症患者电刺激应激后唾液α-淀粉酶和皮质醇的反应性。

• DOI: 10.1055/s-0033-1353157
• 发表时间: 2013
• 期刊: Pharmacopsychiatry.
• 作者: Tamura A;Maruyama Y;Ishitobi Y;Kawano A;Ando T;Ikeda R;Inoue A;Imanaga J;Okamoto S;Kanehisa M;Ninomiya T;Tanaka Y;Tsuru J;Akiyoshi J.
• 通讯作者: Akiyoshi J.

Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in panic disorder patients.

惊恐障碍患者电刺激应激后唾液α-淀粉酶和皮质醇的反应性。

• DOI: 10.1016/j.neures.2012.01.006
• 发表时间: 2012
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: Yoshihiro Tanaka;Yoshinobu Ishitobi;Jotaro Akiyoshi. et al
• 通讯作者: Jotaro Akiyoshi. et al

Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, Inoue A, Imanaga J, Tanaka Y, Tsuru J, Hanada H, Akiyoshi J.

Ishitobi Y、Nakayama S、Kanehisa M、Higuma H、Maruyama Y、Okamoto S、Inoue A、Imanaga J、Tanaka Y、Tsuru J、Hanada H、Akiyoshi J。

• DOI: 10.1097/ypg.0000000000000002
• 发表时间: 2013
• 期刊: Psychiatr Genet.
• 作者: Tamura A;Maruyama Y;Ishitobi Y;Kawano A;Ando T;Ikeda R;Inoue A;Imanaga J;Okamoto S;Kanehisa M;Ninomiya T;Tanaka Y;Tsuru J;Akiyoshi J.;Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.
• 通讯作者: Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.