Research on pathophysiology and mechanisms to develop carbonyl stress-related schizophrenia

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Accumulation of advanced glycation end products, including pentosidine, results from "carbonyl stress," a state featuring an increase in reactive carbonyl compounds and their attendant protein modifications. We found a cross-sectional link, albeit incomplete, between glyoxalase I defect?elicited carbonyl stress and a subgroup of patients with schizophrenia. Thus, agents such as pyridoxamine able to inhibit advanced glycation end product formation or entrap reactive carbonyl compounds may also prove to be of therapeutic value.